泌尿系统中的水通道蛋白。

Aquaporins in Urinary System.

作者信息

Li Yingjie, Wang Weiling, Jiang Tao, Yang Baoxue

机构信息

Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.

State Key Laboratory of Natural and Biomimetic Drugs, and Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.

出版信息

Adv Exp Med Biol. 2017;969:131-148. doi: 10.1007/978-94-024-1057-0_9.

DOI:10.1007/978-94-024-1057-0_9

PMID:28258571

Abstract

Several aquaporin (AQP )-type water channels are expressed in kidney: AQP1 in the proximal tubule, thin descending limb of Henle, and vasa recta; AQP2 -6 in the collecting duct; AQP7 in the proximal tubule; AQP8 in the proximal tubule and collecting duct; and AQP11 in the endoplasmic reticulum of proximal tubule cells. AQP2 is the vasopressin-regulated water channel that is important in hereditary and acquired diseases affecting urine-concentrating ability. The roles of AQPs in renal physiology and transepithelial water transport have been determined using AQP knockout mouse models. This chapter describes renal physiologic insights revealed by phenotypic analysis of AQP knockout mice and the prospects for further basic and clinical studies.

摘要

几种水通道蛋白（AQP）类型的水通道在肾脏中表达：近端小管、髓袢细降支和直小血管中表达AQP1；集合管中表达AQP2 - 6；近端小管中表达AQP7；近端小管和集合管中表达AQP8；近端小管细胞内质网中表达AQP11。AQP2是血管升压素调节的水通道，在影响尿液浓缩能力的遗传性和获得性疾病中起重要作用。利用AQP基因敲除小鼠模型确定了水通道蛋白在肾脏生理学和跨上皮水转运中的作用。本章描述了通过对AQP基因敲除小鼠的表型分析所揭示的肾脏生理学见解以及进一步基础和临床研究的前景。