Huang Boyue, Wang Hongkai, Yang Baoxue
Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China.
Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing, 400016, China.
Adv Exp Med Biol. 2017;969:251-261. doi: 10.1007/978-94-024-1057-0_17.
Water transport through membrane is so intricate that there are still some debates. (Aquaporins) AQPs are entirely accepted to allow water transmembrane movement depending on osmotic gradient. Cotransporters and uniporters , however, are also concerned in water homeotatsis. Urea transporter B (UT-B) has a single-channel water permeability that is similar to AQP1. Cystic fibrosis transmembrane conductance regulator (CFTR ) was initially thought as a water channel but now not believed to transport water directly. By cotranporters, water is transported by water osmosis coupling with substrates, which explains how water is transported across the isolated small intestine. This chapter provides information about water transport mediated by other membrane proteins except AQPs .
水通过细胞膜的运输非常复杂，目前仍存在一些争议。（水通道蛋白）水通道蛋白被完全认为可根据渗透梯度允许水进行跨膜移动。然而，协同转运蛋白和单向转运蛋白也参与水的稳态调节。尿素转运蛋白B（UT-B）具有与水通道蛋白1相似的单通道水通透性。囊性纤维化跨膜传导调节因子（CFTR）最初被认为是一种水通道，但现在不认为它能直接运输水。通过协同转运蛋白，水通过与底物的渗透耦合进行运输，这解释了水如何在离体小肠中运输。本章提供了有关除水通道蛋白外其他膜蛋白介导水运输的信息。
