非水通道蛋白水通道

Non-Aquaporin Water Channels.

作者信息

Huang Boyue, Wang Hongkai, Yang Baoxue

机构信息

Laboratory of Neuroscience and Tissue Engineering, Department of Anatomy, Basic Medical College, Chongqing Medical University, Chongqing, China.

Northwestern University Interdepartmental Neuroscience Program, Chicago, IL, USA.

出版信息

Adv Exp Med Biol. 2023;1398:331-342. doi: 10.1007/978-981-19-7415-1_23.

DOI:10.1007/978-981-19-7415-1_23

PMID:36717505

Abstract

Water transport through membrane is so intricate that there are still some debates. AQPs are entirely accepted to allow water transmembrane movement depending on osmotic gradient. Cotransporters and uniporters, however, are also concerned in water homeostasis. UT-B has a single-channel water permeability that is similar to AQP1. CFTR was initially thought as a water channel but now not believed to transport water directly. By cotransporters, such as KCC4, NKCC1, SGLT1, GAT1, EAAT1, and MCT1, water is transported by water osmosis coupling with substrates, which explains how water is transported across the isolated small intestine. This chapter provides information about water transport mediated by other membrane proteins except AQPs.

摘要

水通过细胞膜的运输非常复杂，至今仍存在一些争议。水通道蛋白（AQPs）被完全认可可根据渗透梯度允许水进行跨膜移动。然而，协同转运蛋白和单向转运蛋白也参与水稳态的维持。尿素转运蛋白B（UT-B）具有与水通道蛋白1（AQP1）相似的单通道水通透性。囊性纤维化跨膜传导调节因子（CFTR）最初被认为是一种水通道，但现在不认为它能直接运输水。通过协同转运蛋白，如钾氯共转运蛋白4（KCC4）、钠钾氯共转运蛋白1（NKCC1）、钠葡萄糖共转运蛋白1（SGLT1）、γ-氨基丁酸转运体1（GAT1）、兴奋性氨基酸转运体1（EAAT1）和单羧酸转运体1（MCT1），水通过与底物的渗透作用耦合进行运输，这解释了水如何在离体小肠中运输。本章提供了除水通道蛋白外其他膜蛋白介导水运输的相关信息。