Akhigbe Taiwo, Zolnourian Ardalan
Clinical Research Fellow, Neurosurgery, University Hospital Southampton, UK.
J Clin Neurosci. 2017 May;39:35-38. doi: 10.1016/j.jocn.2017.02.022. Epub 2017 Feb 28.
Whether surgery improves the outcome more than medical management alone continues to be a subject of intense debate and controversy. However, there is optimism that the management of spontaneous supratentorial intracerebral haemorrhage will change in future based new insight and better understanding of the acute pathophysiology of hematomas and its dynamics. Craniotomy as a surgical approach has been the most studied intervention for spontaneous supratentorial intracerebral haemorrhage but with no significant benefit when compared to best medical management.
A literature search was conducted using electronic data bases including the Cochrane Central Register of Controlled Trials (CENTRAL) on the Cochrane library, MEDLINE and EMBASE. In addition, critical appraisal of most current evidences was carried out.
About 1387 articles identified through database search over 10-year period of which one systematic review and two randomised controlled trials most relevant to this review were critically appraised.
The role of surgery in the management of spontaneous intracerebral haemorrhage still remains a matter of debate. There is insufficient evidence to justify a general policy of early surgery for patients with spontaneous intracerebral haemorrhage compared to initial medical management but STICH did demonstrate that patients with superficial hematoma might benefit from craniotomy.
手术是否比单纯的药物治疗能带来更好的治疗效果仍是一个激烈争论和备受争议的话题。然而,基于对血肿急性病理生理学及其动态变化的新见解和更好理解,人们对未来自发性幕上脑出血的治疗方法改变抱有乐观态度。开颅手术作为一种手术方式,是针对自发性幕上脑出血研究最多的干预措施,但与最佳药物治疗相比并无显著益处。
使用电子数据库进行文献检索,包括Cochrane图书馆中的Cochrane系统评价数据库(CENTRAL)、MEDLINE和EMBASE。此外,对最新证据进行了批判性评价。
在10年期间通过数据库检索确定了约1387篇文章,其中对与本综述最相关的一篇系统评价和两项随机对照试验进行了批判性评价。
手术在自发性脑出血治疗中的作用仍然存在争议。与初始药物治疗相比,尚无足够证据证明对自发性脑出血患者采取早期手术的普遍政策是合理的,但STICH研究确实表明,表浅血肿患者可能从开颅手术中获益。