Hoopes J E, Jabaley M E, Su C T, Wilgis S, Im M J
J Hand Surg Am. 1977 Jan;2(1):62-5. doi: 10.1016/s0363-5023(77)80011-7.
Several enzymes participating in glucose metabolism and some of the acid hydrolases were assayed in palmar fascia and Dupuytren's contracture with fluorometric microanalytical methods. The enzyme activities of glucose metabolism were lower in normal palmar fascia than in dermis. The fascia of Dupuytren's contracture exhibited a general increase in the enzyme activities of glucose catabolism. Little alteration was found in alanine aminotransferase and UDP-glucose dehydrogenase activity in the lesion. Lysosomal hydrolytic enzyme activities were increased five to ten times in Dupuytren's tissue. The dermis overlying Dupuytren's contracture exhibited an increase in the enzyme activities of glucose catabolism, but to a lesser degree than did the fascia of the lesion. The epidermis of involved palmar skin displayed normal enzyme activities.
采用荧光微量分析方法，对掌腱膜和杜普伊特伦挛缩症中的几种参与葡萄糖代谢的酶以及一些酸性水解酶进行了检测。正常掌腱膜中葡萄糖代谢的酶活性低于真皮。杜普伊特伦挛缩症的筋膜显示葡萄糖分解代谢的酶活性普遍增加。病变部位的丙氨酸转氨酶和UDP - 葡萄糖脱氢酶活性变化不大。杜普伊特伦组织中的溶酶体水解酶活性增加了五到十倍。覆盖杜普伊特伦挛缩症的真皮显示葡萄糖分解代谢的酶活性增加，但程度低于病变的筋膜。受累掌部皮肤的表皮显示酶活性正常。
