Huynh Do Luong, Sharma Neelesh, Kumar Singh Amit, Singh Sodhi Simrinder, Zhang Jiao-Jiao, Mongre Raj Kumar, Ghosh Mrinmoy, Kim Nameun, Ho Park Yang, Kee Jeong Dong
Laboratory of Animal Genetic Engineering and Stem Cell Biology, Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju 63243, Republic of Korea.
Division of Veterinary Medicine, Faculty of Veterinary Science & Animal Husbandry, Sher-e-Kashmir University of Agricultural Sciences & Technology, R.S. Pura, Jammu 181102, India.
Chin J Nat Med. 2017 Jan;15(1):15-40. doi: 10.1016/S1875-5364(17)30005-5.
Wogonin is a plant flavonoid compound extracted from Scutellaria baicalensis (Huang-Qin or Chinese skullcap) and has been studied thoroughly by many researchers till date for its anti-viral, anti-oxidant, anti-cancerous and neuro-protective properties. Numerous experiments conducted in vitro and in vivo have demonstrated wogonin's excellent tumor inhibitory properties. The anti-cancer mechanism of wogonin has been ascribed to modulation of various cell signaling pathways, including serine-threonine kinase Akt (also known as protein kinase B) and AMP-activated protein kinase (AMPK) pathways, p53-dependent/independent apoptosis, and inhibition of telomerase activity. Furthermore, wogonin also decreases DNA adduct formation with a carcinogenic compound 2-Aminofluorene and inhibits growth of drug resistant malignant cells and their migration and metastasis, without any side effects. Recently, newly synthesized wogonin derivatives have been developed with impressive anti-tumor activity. This review is the succinct appraisal of the pertinent articles on the mechanisms of anti-tumor properties of wogonin. We also summarize the potential of wogonin and its derivatives used alone or as an adjunct therapy for cancer treatment. Furthermore, pharmacokinetics and side effects of wogonin and its analogues have also been discussed.
汉黄芩素是一种从黄芩中提取的植物黄酮类化合物，迄今为止，许多研究人员已对其抗病毒、抗氧化、抗癌和神经保护特性进行了深入研究。在体外和体内进行的大量实验表明汉黄芩素具有出色的肿瘤抑制特性。汉黄芩素的抗癌机制归因于对多种细胞信号通路的调节，包括丝氨酸 - 苏氨酸激酶Akt（也称为蛋白激酶B）和AMP活化蛋白激酶（AMPK）通路、p53依赖性/非依赖性凋亡以及端粒酶活性的抑制。此外，汉黄芩素还能减少与致癌化合物2-氨基芴形成的DNA加合物，并抑制耐药恶性细胞的生长及其迁移和转移，且无任何副作用。最近，已开发出具有令人印象深刻的抗肿瘤活性的新合成汉黄芩素衍生物。本综述是对有关汉黄芩素抗肿瘤特性机制的相关文章的简要评估。我们还总结了汉黄芩素及其衍生物单独使用或作为癌症治疗辅助疗法的潜力。此外，还讨论了汉黄芩素及其类似物的药代动力学和副作用。
