Esposito E, Cervo L, Petrillo P, Sbacchi M, Tavani A, Samanin R
Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
Brain Res. 1987 Dec 8;436(1):25-9. doi: 10.1016/0006-8993(87)91552-6.
Selective lesions of dopamine (DA) neurons of the nucleus accumbens were made in rats by local injections of 6-hydroxydopamine (6-OHDA). Seven days after 6-OHDA, the binding affinities and capacities at mu-, delta- and kappa-opioid binding sites were determined in the nucleus accumbens by selective labelling techniques. 6-OHDA pretreatment caused a significant increase in the number of delta-opioid binding sites (+30%) while the number of mu-, kappa- and total sites was not modified. The affinity at mu-, delta- and kappa-sites was unchanged after 6-OHDA pretreatment.
通过局部注射6-羟基多巴胺（6-OHDA）在大鼠中制造伏隔核多巴胺（DA）神经元的选择性损伤。在注射6-OHDA七天后，采用选择性标记技术测定伏隔核中μ-、δ-和κ-阿片样物质结合位点的结合亲和力和容量。6-OHDA预处理导致δ-阿片样物质结合位点数量显著增加（增加30%），而μ-、κ-和总结合位点数量未发生改变。6-OHDA预处理后，μ-、δ-和κ-位点的亲和力未发生变化。
