French E D, Pilapil C, Quirion R
Eur J Pharmacol. 1985 Oct 8;116(1-2):1-9. doi: 10.1016/0014-2999(85)90178-5.
[3H]Phencyclidine [( 3H]PCP) binding to rat nucleus accumbens, hippocampal and striatal membranes, and PCP-induced locomotor hyperactivity were assessed following selective lesions of the mesolimbic dopaminergic system. 6-Hydroxydopamine (6-OHDA) injections into the A10 region of the ventral tegmental area or into the accumbens itself resulted in a blockade of PCP's stimulatory effects and a highly significant reduction in the number of [3H]PCP binding sites and dopamine content of the nucleus accumbens. However, destruction of the dopaminergic mesolimbic fibers did not significantly alter hippocampal or striatal [3H]PCP binding. The data suggest that PCP elicits its locomotor stimulating effects via an interaction with PCP binding sites located mostly on mesolimbic dopaminergic terminals within the nucleus accumbens.
在对中脑边缘多巴胺能系统进行选择性损伤后，评估了[3H]苯环利定（[3H]PCP）与大鼠伏隔核、海马和纹状体膜的结合情况以及PCP诱导的运动性活动亢进。向腹侧被盖区的A10区域或伏隔核本身注射6-羟基多巴胺（6-OHDA），导致PCP的刺激作用被阻断，伏隔核中[3H]PCP结合位点的数量和多巴胺含量显著降低。然而，多巴胺能中脑边缘纤维的破坏并没有显著改变海马或纹状体的[3H]PCP结合。数据表明，PCP通过与主要位于伏隔核内中脑边缘多巴胺能终末上的PCP结合位点相互作用，引发其运动刺激作用。
