Bekesi J G, Roboz J P, Fischbein A, Mason P
Department of Neoplastic Diseases, Mount Sinai School of Medicine of the City University of New York, NY 10029.
Cancer Detect Prev Suppl. 1987;1:29-37.
In 1973, inadvertent contamination occurred in a special farm feed supplement for lactating cows. Polybrominated biphenyls (PBBs) were used in place of magnesium oxide resulting in serious harm to farm animals, including cattle, chickens, geese, ducks. Farm families, accustomed to eating their own products, were most heavily exposed. To study the impact of PBBs, 336 adult Michigan farm residents, 117 general consumers for comparison, 75 dairy farm residents in Wisconsin, who had not eaten PBB-contaminated food, were examined, as were 79 healthy subjects in New York City. Abnormalities in the Michigan groups included hypergammaglobulinemia, exaggerated hypersensitive response to streptococci, significant decrease in absolute numbers and percentage of T and B-lymphocytes, and increased number of lymphocytes with no detectable surface markers ("null cells"). Significant reduction of in vitro immune function was noted in 20-25% of the Michigan farm residents who had eaten food containing PBB. The decreased immune function detected among the PBB-exposed farm residents tended to affect families as a unit and was independent of exposed individuals' age or sex, pointing against the possibility of genetic predisposition.
1973年，一种用于泌乳奶牛的特殊农场饲料添加剂发生了意外污染。多溴联苯（PBBs）被误用作氧化镁，对农场动物造成了严重危害，包括牛、鸡、鹅、鸭。习惯食用自家产品的农场家庭受影响最为严重。为了研究多溴联苯的影响，对336名密歇根州成年农场居民、117名作为对照的普通消费者、75名未食用受多溴联苯污染食物的威斯康星州奶牛场居民以及79名纽约市健康受试者进行了检查。密歇根州的人群出现的异常情况包括高球蛋白血症、对链球菌的超敏反应增强、T淋巴细胞和B淋巴细胞的绝对数量和百分比显著下降，以及无明显表面标志物的淋巴细胞（“裸细胞”）数量增加。在食用了含多溴联苯食物的20%至25%的密歇根州农场居民中，观察到体外免疫功能显著降低。在接触多溴联苯的农场居民中检测到的免疫功能下降往往以家庭为单位受到影响，且与接触者的年龄或性别无关，这排除了遗传易感性的可能性。
