Department of Neurology, St. Josef Hospital, Ruhr-University of Bochum, Bochum, Germany.
Institute of Diagnostic and Interventional Radiology, St. Josef Hospital, Ruhr-University of Bochum, Bochum, Germany.
Mult Scler. 2017 Mar;23(3):483-486. doi: 10.1177/1352458516678475. Epub 2016 Nov 12.
We report the case of a post-progressive multifocal leukoencephalopathy (PML), multiple sclerosis (MS) patient with an uncomplicated pregnancy and delivery. A 28-year-old woman on natalizumab (total of 49 infusions) was diagnosed with PML due to typical magnetic resonance imaging (MRI) and clinical presentation. John Cunningham virus (JCV) was detected in the cerebrospinal fluid (CSF) during the immune reconstitution inflammatory syndrome (IRIS). Nine months after PML onset, JCV negativity in the CSF was observed. MS was stabilised with dimethyl fumarate (DMF), and 18 months later, a desired pregnancy was reported, resulting in the birth of a healthy boy. Our report gives new hope regarding family planning for post-PML patients.
我们报告了一例妊娠和分娩过程无并发症的进展性多灶性白质脑病（PML）、多发性硬化症（MS）患者。一名 28 岁的女性患者接受了纳武利尤单抗（总共输注 49 次）治疗，因典型的磁共振成像（MRI）和临床表现而被诊断为 PML。在免疫重建炎症综合征（IRIS）期间，在脑脊液（CSF）中检测到约翰·坎宁安病毒（JCV）。PML 发病后 9 个月，CSF 中的 JCV 检测结果为阴性。MS 用二甲基富马酸酯（DMF）稳定，18 个月后，患者报告了一次理想的妊娠，生下了一个健康的男孩。我们的报告为 PML 患者的计划生育带来了新的希望。
