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移植肝中的枝双腔吸虫:一项罕见发现的报告。

Dicrocoelium Dentriticum in Explanted Liver: Report of an Unusual Finding.

作者信息

Azmoudeh-Ardalan Farid, Soleimani Vahid, Jahanbin Behnaz

机构信息

Pathology Department, Cancer Research Institute, Liver Transplant Research Center, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Exp Clin Transplant. 2017 Feb;15(Suppl 1):178-181. doi: 10.6002/ect.mesot2016.P62.

Abstract

Dicrocoelium dentriticum, a member of trematode type helminths, is a liver parasite of ruminants. Humans are infected accidentally by ingestion of intermediate host, through infected ants via eating of raw vegetables or drinking of contaminated water. Infection is often asymptomatic or results in subtle symptoms; therefore, infections are usually unrecognized. However, it can produce chronic cholangitis and swelling or adenomatous proliferation in the bile ducts and lead to abdominal pain, diarrhea, fatigue, jaundice, and other symptoms. We report a 49-year-old female patient with end-stage hepatic cirrhosis from viral hepatitis B and D coinfection who underwent liver transplant. Shortly after transplant, she developed symptoms suggesting an obstructed biliary duct. Liver needle biopsy was done 24 hours after transplant to rule out rejection. Biopsy of her explanted liver was also examined pathologically. Microscopic examination of the liver needle biopsy ruled out rejection. Prepared sections of explanted liver revealed a helminth in the common bile duct. Morphologic reconstruction of helminth by microscopic findings and consultation with an expert parasitologist supported the diagnosis of Dicrocoelium dentriticum.

摘要

枝双腔吸虫是吸虫类蠕虫的一种,是反刍动物的肝脏寄生虫。人类因误食中间宿主而意外感染,通过食用生蔬菜或饮用受污染的水摄入感染的蚂蚁。感染通常无症状或仅导致轻微症状;因此,感染往往未被察觉。然而,它可引发慢性胆管炎以及胆管肿胀或腺瘤样增生,并导致腹痛、腹泻、乏力、黄疸及其他症状。我们报告一名49岁女性患者,她因乙型和丁型肝炎病毒合并感染导致终末期肝硬化,接受了肝移植手术。移植后不久,她出现了提示胆管梗阻的症状。移植后24小时进行了肝穿刺活检以排除排斥反应。还对其切除的肝脏进行了病理检查。肝穿刺活检的显微镜检查排除了排斥反应。切除肝脏的制备切片显示胆总管中有一条蠕虫。通过显微镜检查结果进行蠕虫形态重建,并咨询寄生虫学专家,支持了枝双腔吸虫的诊断。

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