1型糖尿病患者接受胎儿胰腺干细胞移植后的瘦素水平

Leptin Levels in Patients with Type 1 Diabetes Mellitus After Fetal Pancreatic Stem Cell Transplant.

作者信息

Ulyanova Olga, Baigenzhin Abay, Taubaldieva Zhannat, Tuganbekova Saltanat, Kozina Larissa, Saparbayev Samat

机构信息

Department of Internal Medicine, National Scientific Medical Research Center, Astana, Kazakhstan.

出版信息

Exp Clin Transplant. 2017 Feb;15(Suppl 1):194-195. doi: 10.6002/ect.mesot2016.P77.

DOI:10.6002/ect.mesot2016.P77

PMID:28260466

Abstract

OBJECTIVES

Our objective was to determine leptin levels in patients with type 1 diabetes mellitus after fetal pancreatic stem cell transplant.

MATERIALS AND METHODS

Seven patients, aged 20 to 42 years, with type 1 diabetes mellitus received a fetal pancreatic stem cell transplant by intravenous infusion. The quantity of fetal stem cells infused was ≥ 5 × 10⁶, and the cells were of 12 to 14 weeks of gestation. We analyzed the levels of leptin, C-peptide, and antibodies to the islets of Langerhans before and 3 months after the transplant procedure.

RESULTS

Fetal pancreatic stem cell transplant led to significant increases in leptin and C-peptide levels, from 4.63 ± 1.17 ng/mL and 0.09 ± 0.02 ng/mL to 7.71 ± 1.45 ng/mL (P < .05) and 0.22 ± 0.05 ng/mL (P < .005), respectively, without an increase in antibodies to the islets of Langerhans, which measured 0.64 ± 0.13 U/mL before transplant and 0.57 ± 0.18 U/mL 3 months later (P > .05).

CONCLUSIONS

Leptin levels increase significantly within 3 months of fetal pancreatic stem cell transplant in patients with type 1 diabetes mellitus.

摘要

目的

我们的目的是确定1型糖尿病患者在接受胎儿胰腺干细胞移植后的瘦素水平。

材料与方法

7例年龄在20至42岁之间的1型糖尿病患者通过静脉输注接受了胎儿胰腺干细胞移植。输注的胎儿干细胞数量≥5×10⁶，细胞来自妊娠12至14周的胎儿。我们分析了移植手术前和术后3个月的瘦素、C肽以及抗胰岛细胞抗体水平。

结果

胎儿胰腺干细胞移植导致瘦素和C肽水平显著升高，分别从4.63±1.17 ng/mL和0.09±0.02 ng/mL升至7.71±1.45 ng/mL（P<.05）和0.22±0.05 ng/mL（P<.005），而抗胰岛细胞抗体水平没有升高，移植前为0.64±0.13 U/mL，3个月后为0.57±0.18 U/mL（P>.05）。