胎儿胰腺干细胞移植后2型糖尿病患者体内的转化生长因子β1

Transforming Growth Factor β1 in Patients with Type 2 Diabetes Mellitus After Fetal Pancreatic Stem Cell Transplant.

作者信息

Ulyanova Olga, Baigenzhin Abay, Doskaliyev Zhaksylyk, Karibekov Temirlan, Kozina Larissa, Saparbayev Samat, Trimova Rakhat

机构信息

Department of Endocrine Disturbances, National Scientific Medical Research Center, Astana, Kazakhstan.

出版信息

Exp Clin Transplant. 2018 Mar;16 Suppl 1(Suppl 1):168-170. doi: 10.6002/ect.TOND-TDTD2017.P49.

DOI:10.6002/ect.TOND-TDTD2017.P49

PMID:29528020

Abstract

OBJECTIVES

Our objective was to determine transforming growth factor β1 levels in patients with type 2 diabetes mellitus after fetal pancreatic stem cell transplant.

MATERIALS AND METHODS

We examined 10 patients (age range, 41-65 y) with type 2 diabetes mellitus, which we subsequently divided into 2 groups. Group 1 comprised 5 patients who received fetal pancreatic stem cell transplant (cells were 16-18 wk gestation) performed by intravenous infusion. Group 2 comprised 5 patients (control group) who were on hypoglycemic tablet therapy or insulin therapy. The quantity of fetal stem cells infused was 5 to 6 × 106. We analyzed transforming growth factor β1, C-peptide, and glycated hemoglobin levels in patients before and 3 months after fetal pancreatic stem cell transplant.

RESULTS

In patients with type 2 diabetes mellitus, fetal pancreatic stem cell transplant led to a significant increase in transforming growth factor β1 levels, from 16 364.8 to 35 730.4 ng/mL (P = .008), with trend in decreased glycated hemoglobin levels, from 7.96% to 6.98% (P = .088) after 3 months.

CONCLUSIONS

Transforming growth factor β1 levels increased significantly within 3 months after fetal pancreatic stem cell transplant in patients with type 2 diabetes mellitus.

摘要

目的

我们的目的是确定胎儿胰腺干细胞移植后2型糖尿病患者体内转化生长因子β1的水平。

材料与方法

我们检查了10例2型糖尿病患者（年龄范围41 - 65岁），随后将他们分为2组。第1组包括5例接受胎儿胰腺干细胞移植的患者（细胞来自妊娠16 - 18周的胎儿），通过静脉输注进行移植。第2组包括5例患者（对照组），他们接受降糖片剂治疗或胰岛素治疗。输注的胎儿干细胞数量为5至6×10⁶。我们分析了胎儿胰腺干细胞移植前及移植后3个月患者体内转化生长因子β1、C肽和糖化血红蛋白的水平。