Fujii Yukiko, Harada Kouji H, Haraguchi Koichi, Koizumi Akio
Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo, Kyoto, 606-8501, Japan; Daiichi University of Pharmacy, Tamagawa-cho 22-1, Minami-ku, Fukuoka, 815-8511, Japan.
Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida Konoe, Sakyo, Kyoto, 606-8501, Japan.
Chemosphere. 2017 Jun;176:165-174. doi: 10.1016/j.chemosphere.2017.02.073. Epub 2017 Feb 17.
We investigated temporal changes of perfluoroalkyl carboxylic acids (PFCAs) with 8-14 carbon atoms (C8 to C14) in duplicate diet and serum samples in Japan. The sum dietary intakes of PFCAs (C8 to C13) in the Kansai and Tohoku region were highest in the 2010s (mean; 177 ng/day for Kansai, 107 ng/day for Tohoku) followed by the 2000s (77 ng/day for Kansai, 34 ng/day for Tohoku) and the 1990s (53 ng/day for Kansai, 58 ng/day for Tohoku), then the 1980s (19 ng/day for Kansai, 23 ng/day for Tohoku). The sum of the serum concentartions (C8 to C13) was also highest in the 2010s (mean; 17 ng/mL for Kansai, 7.4 ng/mL for Tohoku), followed by the 2000s (12 ng/mL for Kansai, 6.3 ng/mL for Tohoku), then the 1990s (6.8 ng/mL for Kansai, 5.5 mg/mL for Tohoku) and the 1980s (3.8 ng/mL for Kansai, 0.4 ng/mL for Tohoku). A positive correlation was observed between dietary intakes and serum concentration for C8 to C11 (r = 0.94, p < 0.05 for C8; r = 0.80, p < 0.05 for C9; r = 0.98, p < 0.05 for C10; and r = 0.84, p < 0.05 for C11). The levels of C8, C9 and C10 in serum and dietary intake in the 2010s were much higher in Kansai than those in Tohoku, although those of C11 did not show such differences. Kansai has a fluoropolymer manufacture known as a specific source of PFOA (C8), and is more urbanized than Tohoku, which may be attributed to the higher levels of PFCAs (C8 to C10). On the other hand, C11 is common to residents in Kansai and Tohoku.
我们调查了日本重复采集的饮食和血清样本中含8至14个碳原子（C8至C14）的全氟烷基羧酸（PFCA）的时间变化情况。关西地区和东北地区PFCA（C8至C13）的饮食摄入量总和在2010年代最高（平均值；关西地区为177纳克/天，东北地区为107纳克/天），其次是2000年代（关西地区为77纳克/天，东北地区为34纳克/天）和1990年代（关西地区为53纳克/天，东北地区为58纳克/天），然后是1980年代（关西地区为19纳克/天，东北地区为23纳克/天）。血清浓度总和（C8至C13）在2010年代也最高（平均值；关西地区为17纳克/毫升，东北地区为7.4纳克/毫升），其次是2000年代（关西地区为12纳克/毫升，东北地区为6.3纳克/毫升），然后是1990年代（关西地区为6.8纳克/毫升，东北地区为5.5纳克/毫升）和1980年代（关西地区为3.8纳克/毫升，东北地区为0.4纳克/毫升）。观察到C8至C11的饮食摄入量与血清浓度之间存在正相关（C8：r = 0.94，p < 0.05；C9：r = 0.80，p < 0.05；C10：r = 0.98，p < 0.05；C11：r = 0.84，p < 0.05）。2010年代关西地区血清中C8、C9和C10的水平以及饮食摄入量远高于东北地区，尽管C11的水平未显示出这种差异。关西地区有一家氟聚合物制造商，是全氟辛酸（PFOA, C8）的一个特定来源，且比东北地区城市化程度更高，这可能是PFCA（C8至C10）水平较高的原因。另一方面，C11在关西地区和东北地区居民中很常见。
