Fujii Yukiko, Harada Kouji H, Kobayashi Hatasu, Haraguchi Koichi, Koizumi Akio
Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto 606-8501, Japan.
Department of Pharmaceutical Sciences, Daiichi University of Pharmacy, Fukuoka 815-8511, Japan.
Toxics. 2020 Apr 1;8(2):23. doi: 10.3390/toxics8020023.
Perfluoroalkyl carboxylic acids (PFCAs), such as perfluorooctanoic acid (PFOA, C8), are a group of industrial chemicals that are detected in the serum of people throughout the world. Long-chain PFCAs (C9 to C13) have high lipophilicity, therefore they may have a high transfer rate to breast milk. This study investigated the lactational transfer of PFCAs with carbon chain lengths of 8 to 13 in mice. Lactating dams were given a single intravenous administration of PFCAs (C8 to C13) during the postnatal period (8-13 days after delivery). Milk was collected from the dam 24 h after administration using a milking device built in-house. Plasma was obtained from the dam at the same time as milk collection. The observed milk/plasma (M/P) concentration ratios were 0.32 for C8, 0.30 for C9, 0.17 for C10, 0.21 for C11, 0.32 for C12, and 0.49 for C13. These results indicate that the M/P concentration ratio is not related to the lipophilicity of PFCAs. However, estimated relative daily intake, an indicator of how much PFCA is transferred from dams to pups per body weight, increased with chain length: 4.16 for C8, 8.98 for C9, 9.35 for C10, 9.51 for C11, 10.20 for C12, and 10.49 for C13, which may be related to the lower clearance of long-chain PFCAs. These results indicate the importance of future risk assessment of long-chain PFCAs.
全氟烷基羧酸（PFCA），如全氟辛酸（PFOA，C8），是一类在全世界人们血清中都能检测到的工业化学品。长链全氟烷基羧酸（C9至C13）具有高亲脂性，因此它们向母乳的转移率可能很高。本研究调查了碳链长度为8至13的全氟烷基羧酸在小鼠体内的泌乳期转移情况。在产后时期（分娩后8 - 13天），给哺乳母鼠单次静脉注射全氟烷基羧酸（C8至C13）。给药24小时后，使用自制的挤奶装置从母鼠收集乳汁。在收集乳汁的同时从母鼠获取血浆。观察到的乳汁/血浆（M/P）浓度比，C8为0.32，C9为0.30，C10为0.17，C11为0.21，C12为0.32，C13为0.49。这些结果表明M/P浓度比与全氟烷基羧酸的亲脂性无关。然而，估计相对每日摄入量是一个表示每体重全氟烷基羧酸从母鼠转移到幼崽体内量的指标，它随碳链长度增加：C8为4.16，C9为8.98，C10为9.35，C11为9.51，C12为10.20，C13为10.49，这可能与长链全氟烷基羧酸较低的清除率有关。这些结果表明了未来对长链全氟烷基羧酸进行风险评估的重要性。
