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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Baraldi M, Zeneroli M L, Ventura E, Vezzelli C

Department of Pharmaceutical Sciences, Modena University, Italy.

Clin Sci (Lond). 1987 Dec;73(6):669-71. doi: 10.1042/cs0730669.

In the search to identify peripheral toxins which could be responsible for the supersensitivity of brain benzodiazepine receptors in experimental models of hepatic encephalopathy, [3H]diazepam-binding studies have been performed on brain tissues of normal rats treated with ammonium chloride, dimethyldisulphide and octanoic acid administered alone or in combination. 2. The subacute administration of the three toxins in combination induced a 30% increase in the number of benzodiazepine recognition sites. The administration of these toxins alone or in combination showed that this increase was mainly linked to the synergistic action of dimethyldisulphide or octanoic acid with ammonia, since dimethyldisulphide plus octanoic acid was ineffective. 3. These observations seem to reinforce the suggestion that these three toxins are able to induce neurochemical derangements similar to those described in experimental hepatic encephalopathy.

在寻找可能导致肝性脑病实验模型中脑苯二氮䓬受体超敏的外周毒素的过程中，对单独或联合给予氯化铵、二甲基二硫和辛酸的正常大鼠脑组织进行了[3H]地西泮结合研究。2. 三种毒素联合亚急性给药导致苯二氮䓬识别位点数量增加30%。单独或联合给予这些毒素表明，这种增加主要与二甲基二硫或辛酸与氨的协同作用有关，因为二甲基二硫加辛酸无效。3. 这些观察结果似乎支持了这样的观点，即这三种毒素能够诱发与实验性肝性脑病中所描述的类似的神经化学紊乱。

Baraldi M, Zeneroli M L, Ventura E, Vezzelli C

Department of Pharmaceutical Sciences, Modena University, Italy.

Clin Sci (Lond). 1987 Dec;73(6):669-71. doi: 10.1042/cs0730669.

In the search to identify peripheral toxins which could be responsible for the supersensitivity of brain benzodiazepine receptors in experimental models of hepatic encephalopathy, [3H]diazepam-binding studies have been performed on brain tissues of normal rats treated with ammonium chloride, dimethyldisulphide and octanoic acid administered alone or in combination. 2. The subacute administration of the three toxins in combination induced a 30% increase in the number of benzodiazepine recognition sites. The administration of these toxins alone or in combination showed that this increase was mainly linked to the synergistic action of dimethyldisulphide or octanoic acid with ammonia, since dimethyldisulphide plus octanoic acid was ineffective. 3. These observations seem to reinforce the suggestion that these three toxins are able to induce neurochemical derangements similar to those described in experimental hepatic encephalopathy.

在寻找可能导致肝性脑病实验模型中脑苯二氮䓬受体超敏的外周毒素的过程中，对单独或联合给予氯化铵、二甲基二硫和辛酸的正常大鼠脑组织进行了[3H]地西泮结合研究。2. 三种毒素联合亚急性给药导致苯二氮䓬识别位点数量增加30%。单独或联合给予这些毒素表明，这种增加主要与二甲基二硫或辛酸与氨的协同作用有关，因为二甲基二硫加辛酸无效。3. 这些观察结果似乎支持了这样的观点，即这三种毒素能够诱发与实验性肝性脑病中所描述的类似的神经化学紊乱。