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超越卫生学：共生微生物群与过敏性疾病

Beyond Hygiene: Commensal Microbiota and Allergic Diseases.

作者信息

Hong Sung-Wook, Kim Kwang Soon, Surh Charles D

机构信息

Academy of Immunology and Microbiology, Institute for Basic Science, Pohang University of Science and Technology, Pohang 37673, Korea.

Academy of Immunology and Microbiology, Institute for Basic Science, Pohang University of Science and Technology, Pohang 37673, Korea.; Department of Integrative Biosciences and Biotechnology. Pohang University of Science and Technology, Pohang 37673, Korea.

出版信息

Immune Netw. 2017 Feb;17(1):48-59. doi: 10.4110/in.2017.17.1.48. Epub 2017 Feb 23.

DOI:10.4110/in.2017.17.1.48
PMID:28261020
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5334122/
Abstract

Complex communities of microorganisms, termed commensal microbiota, inhabit mucosal surfaces and profoundly influence host physiology as well as occurrence of allergic diseases. Perturbing factors such as the mode of delivery, dietary fibers and antibiotics can influence allergic diseases by altering commensal microbiota in affected tissues as well as in intestine. Here, we review current findings on the relationship between commensal microbiota and allergic diseases, and discuss the underlying mechanisms that contribute to the regulation of allergic responses by commensal microbiota.

摘要

被称为共生微生物群的复杂微生物群落栖息于黏膜表面，对宿主生理以及过敏性疾病的发生有着深远影响。诸如分娩方式、膳食纤维和抗生素等干扰因素可通过改变受影响组织以及肠道中的共生微生物群来影响过敏性疾病。在此，我们综述了目前关于共生微生物群与过敏性疾病之间关系的研究结果，并讨论了共生微生物群调节过敏反应的潜在机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e01/5334122/7d61629406e3/in-17-48-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e01/5334122/b53c08ee56db/in-17-48-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e01/5334122/7d61629406e3/in-17-48-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e01/5334122/b53c08ee56db/in-17-48-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1e01/5334122/7d61629406e3/in-17-48-g002.jpg

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