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核心技术专利：CN118964589B侵权必究
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硼酸修饰的藻酸盐能够直接形成可注射、自修复和多重刺激响应的水凝胶。

Boronic acid-modified alginate enables direct formation of injectable, self-healing and multistimuli-responsive hydrogels.

机构信息

Institute of Organic Chemistry, University of Regensburg, Universitaetsstr. 31, 93040 Regensburg, Germany.

IQAC-CSIC, Jordi Girona 18-26, Barcelona 08034, Spain and Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER BBN), Spain.

出版信息

Chem Commun (Camb). 2017 Mar 16;53(23):3350-3353. doi: 10.1039/c7cc00765e.

DOI:10.1039/c7cc00765e
PMID:28261723
Abstract

One-step functionalization of alginate with boronic acid groups allowed spontaneous formation of biocompatible hydrogels under basic conditions without additional complementary molecules or crosslinking agents. The dynamic nature of boronate ester bonds formed with vicinal diols present on alginate pyranose rings provided remarkable self-healing, injectable and multi-stimuli responsive properties to the material.

摘要

海藻酸钠与硼酸基团的一步功能化允许在碱性条件下自发形成生物相容性水凝胶，而无需额外的互补分子或交联剂。在海藻酸钠吡喃糖环上的邻二醇形成的硼酸酯键的动态性质为该材料提供了显著的自修复、可注射和多重刺激响应性能。

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Boronic acid-modified alginate enables direct formation of injectable, self-healing and multistimuli-responsive hydrogels.

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[10]
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[3]
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Biomacromolecules. 2025-1-13

[4]
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Gels. 2024-10-2

[5]
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[6]
Boronate Ester Hydrogels for Biomedical Applications: Challenges and Opportunities.

Chem Mater. 2024-7-9

[7]
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Gels. 2023-10-10

[8]
Self-Supporting Hyaluronic Acid-Functionalized G-Quadruplex-Based Perfusable Multicomponent Hydrogels Embedded in Photo-Cross-Linkable Matrices for Bioapplications.

Biomacromolecules. 2023-7-10

[9]
Dynamic Alginate Hydrogel as an Antioxidative Bioink for Bioprinting.

Gels. 2023-4-7

[10]
Cross-Linking of Sugar-Derived Polyethers and Boronic Acids for Renewable, Self-Healing, and Single-Ion Conducting Organogel Polymer Electrolytes.

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