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抑制雄激素受体复合物与核染色质结合并促进其从核染色质释放的蛋白质因子。

Protein factor that inhibits binding and promotes release of androgen-receptor complex from nuclear chromatin.

作者信息

Shyr C I, Liao S

出版信息

Proc Natl Acad Sci U S A. 1978 Dec;75(12):5969-73. doi: 10.1073/pnas.75.12.5969.

DOI:10.1073/pnas.75.12.5969
PMID:282618
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC393098/
Abstract

A protein factor that can inhibit binding of the androgen-receptor complex to the nuclear chromatin has been isolated from the cytosol of the ventral prostate of rats. The inhibition is reversible and not caused by an irreversible destruction of the receptor or the chromatin. The inhibitor also can promote, by a temperature-dependent process, the release of steroid-receptor complex already bound to chromatin. It is conceivable that such a protein factor plays a regulatory role in the nuclear-cytoplasmic recycling or chromatin binding of the steroid hormone receptor.

摘要

一种能够抑制雄激素受体复合物与核染色质结合的蛋白质因子已从大鼠腹侧前列腺的胞质溶胶中分离出来。这种抑制作用是可逆的，并非由受体或染色质的不可逆破坏引起。该抑制剂还可通过一个温度依赖性过程促进已与染色质结合的类固醇受体复合物的释放。可以想象，这样一种蛋白质因子在类固醇激素受体的核质循环或与染色质的结合中发挥着调节作用。

相似文献

1
Protein factor that inhibits binding and promotes release of androgen-receptor complex from nuclear chromatin.抑制雄激素受体复合物与核染色质结合并促进其从核染色质释放的蛋白质因子。
Proc Natl Acad Sci U S A. 1978 Dec;75(12):5969-73. doi: 10.1073/pnas.75.12.5969.
2
Prostate alpha-protein: subunit structure, polyamine binding, and inhibition of nuclear chromatin binding of androgen-receptor complex.前列腺α蛋白：亚基结构、多胺结合以及对雄激素受体复合物核染色质结合的抑制作用
J Steroid Biochem. 1979 Jul;11(1B):401-5. doi: 10.1016/0022-4731(79)90058-x.
3
Intracellular inactivation, reactivation and dynamic status of prostate androgen receptors.前列腺雄激素受体的细胞内失活、再激活及动态状态
Biochem J. 1982 Nov 15;208(2):383-92. doi: 10.1042/bj2080383.
4
Interaction of androgen-binding cytosol proteins of rat prostate.大鼠前列腺雄激素结合胞质蛋白的相互作用
J Steroid Biochem. 1978 Jan;9(1):53-8. doi: 10.1016/0022-4731(78)90102-4.
5
Binding of cytoplasmic 5alpha-dihydrotestosterone-receptor complex by nuclei from the ventral prostate, liver, and spleen of rats.大鼠腹侧前列腺、肝脏和脾脏的细胞核对细胞质5α-二氢睾酮受体复合物的结合作用。
J Biochem. 1977 Apr;81(4):879-84. doi: 10.1093/oxfordjournals.jbchem.a131552.
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Androgen-dependent regulation of androgen nuclear receptor in the rat ventral prostate.大鼠腹侧前列腺中雄激素对雄激素核受体的依赖性调节。
Endocrinology. 1982 Jun;110(6):1926-32. doi: 10.1210/endo-110-6-1926.
7
The role of nonhistone chromosomal proteins in the interaction of prostate chromatin with androgen.receptor complex.非组蛋白染色体蛋白在前列腺染色质与雄激素受体复合物相互作用中的作用。
Biochim Biophys Acta. 1978 Mar 29;518(1):81-8. doi: 10.1016/0005-2787(78)90117-x.
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Androgen receptor binding to nuclear matrix in vitro and its inhibition by 8S androgen receptor promoting factor.雄激素受体在体外与核基质的结合及其受8S雄激素受体促进因子的抑制作用。
Biochemistry. 1984 Jul 17;23(15):3479-86. doi: 10.1021/bi00310a015.
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Cellular dynamics of androgen receptor and protein induction in rat ventral prostate.大鼠腹侧前列腺中雄激素受体的细胞动力学及蛋白诱导
Prog Clin Biol Res. 1981;75A:381-9.
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Characterization of androgen receptor and estramustine binding protein of rat ventral prostatic tissue in organ culture.器官培养中大鼠前列腺腹侧组织雄激素受体和雌莫司汀结合蛋白的特性研究
J Steroid Biochem. 1981 Mar;14(3):251-60. doi: 10.1016/0022-4731(81)90133-3.

引用本文的文献

1
Androgen regulation of prostatic binding protein messenger RNA studied by using cloned complementary DNA.利用克隆的互补DNA研究雄激素对前列腺结合蛋白信使核糖核酸的调节作用。
Mol Cell Biochem. 1983;56(2):145-54. doi: 10.1007/BF00227215.
2
Presence of oestrogen receptors on target cells and antiproliferative activity of estramustine phosphate: positive correlation for human tumours in vitro.靶细胞上雌激素受体的存在及磷酸雌莫司汀的抗增殖活性：体外人肿瘤的正相关关系
J Cancer Res Clin Oncol. 1991;117(3):244-8. doi: 10.1007/BF01625432.

本文引用的文献

1
Rapid effect of testosterone on ribonucleic acid polymerase activity of rat ventral prostate.睾酮对大鼠前列腺腹叶核糖核酸聚合酶活性的快速作用
Endocrinology. 1965 Oct;77(4):763-5. doi: 10.1210/endo-77-4-763.
2
Androgen receptors. Steroid- and tissue-specific retention of a 17 beta-hydroxy-5 alpha-androstan-3-one-protein complex by the cell nuclei of ventral prostate.雄激素受体。17β-羟基-5α-雄甾烷-3-酮-蛋白质复合物在前列腺腹侧细胞核中的类固醇和组织特异性滞留。
J Biol Chem. 1971 Jan 10;246(1):16-24.
3
Retention of an androgen-protein complex by nuclear chromatin aggregates: heat-labile factors.核染色质聚集体对雄激素 - 蛋白质复合物的保留：热不稳定因子。
Biochim Biophys Acta. 1971 Dec 21;252(3):607-11. doi: 10.1016/0304-4165(71)90168-1.
4
The role of estrophilin in estrogen action.雌激素受体蛋白在雌激素作用中的角色。
Vitam Horm. 1974;32:89-127. doi: 10.1016/s0083-6729(08)60007-2.
5
Estrogen receptor binding to isolated nuclei. A nonsaturable process.雌激素受体与分离细胞核的结合。一个非饱和过程。
Biochemistry. 1974 Jan 15;13(2):327-31. doi: 10.1021/bi00699a016.
6
Steroid structure and androgenic activity. Specificities involved in the receptor binding and nuclear retention of various androgens.类固醇结构与雄激素活性。各种雄激素在受体结合及核内滞留方面所涉及的特异性。
J Biol Chem. 1973 Sep 10;248(17):6154-62.
7
The use of deoxyribonucleic acid-cellulose chromatography and isoelectric focusing for the characterization and partial purification of steroid-receptor complexes.利用脱氧核糖核酸-纤维素色谱法和等电聚焦法对类固醇受体复合物进行表征和部分纯化。
Biochem J. 1973 May;134(1):113-27. doi: 10.1042/bj1340113.
8
Ribonucleoprotein binding of steroid-"receptor" complexes.类固醇“受体”复合物的核糖核蛋白结合
Nat New Biol. 1973 Feb 14;241(111):211-3. doi: 10.1038/newbio241211a0.
9
Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.人红细胞膜主要多肽的电泳分析。
Biochemistry. 1971 Jun 22;10(13):2606-17. doi: 10.1021/bi00789a030.
10
Role of nuclear proteins as high affinity sites ("acceptors") for progesterone in the avian oviduct.核蛋白在鸟类输卵管中作为孕酮高亲和力位点（“受体”）的作用。
J Steroid Biochem. 1976 Nov-Dec;7(11-12):1091-101. doi: 10.1016/0022-4731(76)90039-x.