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Anti-parkinsonian agents are phencyclidine agonists and N-methyl-aspartate antagonists.

作者信息

Olney J W, Price M T, Labruyere J, Salles K S, Frierdich G, Mueller M, Silverman E

机构信息

Washington University School of Medicine, St. Louis, MO.

出版信息

Eur J Pharmacol. 1987 Oct 13;142(2):319-20. doi: 10.1016/0014-2999(87)90123-3.

DOI:10.1016/0014-2999(87)90123-3
PMID:2826182
Abstract
摘要

相似文献

1
Anti-parkinsonian agents are phencyclidine agonists and N-methyl-aspartate antagonists.抗帕金森病药物是苯环己哌啶激动剂和N-甲基-D-天冬氨酸拮抗剂。
Eur J Pharmacol. 1987 Oct 13;142(2):319-20. doi: 10.1016/0014-2999(87)90123-3.
2
Molecular target size of NMDA antagonist binding sites.N-甲基-D-天冬氨酸拮抗剂结合位点的分子靶点大小
Eur J Pharmacol. 1987 Apr 7;136(1):137-8. doi: 10.1016/0014-2999(87)90793-x.
3
Linkage between phencyclidine (PCP) and N-methyl-D-aspartate (NMDA) receptors in the cerebellum.
Brain Res. 1988 Mar 29;445(1):147-51. doi: 10.1016/0006-8993(88)91084-0.
4
High correlation between the localization of [3H]TCP binding and NMDA receptors.[3H]TCP结合位点与N-甲基-D-天冬氨酸受体的定位之间存在高度相关性。
Eur J Pharmacol. 1986 Apr 9;123(1):173-4. doi: 10.1016/0014-2999(86)90703-x.
5
Neuropharmacology of phencyclidine: basic mechanisms and therapeutic potential.苯环己哌啶的神经药理学：基本机制与治疗潜力
Annu Rev Pharmacol Toxicol. 1990;30:707-50. doi: 10.1146/annurev.pa.30.040190.003423.
6
Kinetic characterization of the phencyclidine-N-methyl-D-aspartate receptor interaction: evidence for a steric blockade of the channel.苯环利定与N-甲基-D-天冬氨酸受体相互作用的动力学特征：通道空间位阻的证据
Biochemistry. 1988 Feb 9;27(3):843-8. doi: 10.1021/bi00403a001.
7
Antagonism of N-methyl-D-aspartate (NMDA) evoked increases in cerebellar cGMP and striatal ACh release by phencyclidine (PCP) receptor agonists: evidence for possible allosteric coupling of NMDA and PCP receptors.
Can J Physiol Pharmacol. 1987 Sep;65(9):1923-7. doi: 10.1139/y87-299.
8
A phencyclidine recognition site is associated with N-methyl-D-aspartate inhibition of carbachol-stimulated phosphoinositide hydrolysis in rat cortical slices.
Mol Pharmacol. 1989 Jun;35(6):787-94.
9
Cycloleucine competitively antagonizes the strychnine-insensitive glycine receptor.环亮氨酸竞争性拮抗士的宁不敏感的甘氨酸受体。
Eur J Pharmacol. 1988 Jun 22;151(1):165-6. doi: 10.1016/0014-2999(88)90713-3.
10
mRNA from NCB-20 cells encodes the N-methyl-D-aspartate/phencyclidine receptor: a Xenopus oocyte expression study.来自NCB - 20细胞的信使核糖核酸编码N - 甲基 - D - 天冬氨酸/苯环利定受体：一项非洲爪蟾卵母细胞表达研究。
Proc Natl Acad Sci U S A. 1989 Mar;86(5):1708-11. doi: 10.1073/pnas.86.5.1708.

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(R,S)-trihexyphenidyl, acting via a muscarinic receptor-independent mechanism, inhibits hippocampal glutamatergic and GABAergic synaptic transmissions: Potential relevance for treatment of organophosphorus intoxication.(R,S)-三己芬迪，通过一种非毒蕈碱型受体机制发挥作用，抑制海马谷氨酸能和 GABA 能突触传递：对有机磷中毒治疗的潜在相关性。
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Behavioral side effects of prophylactic therapies against soman-induced seizures and lethality in rats.大鼠中针对梭曼诱发的癫痫发作和致死性的预防性治疗的行为副作用。
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NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity.
N-甲基-D-天冬氨酸受体拮抗剂解除大鼠后扣带回和压后皮质的抑制：一种潜在的神经毒性机制。
J Neurosci. 2002 Apr 15;22(8):3070-80. doi: 10.1523/JNEUROSCI.22-08-03070.2002.
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Interactions of excitatory amino acid antagonists with conventional antiepileptic drugs.兴奋性氨基酸拮抗剂与传统抗癫痫药物的相互作用。
Metab Brain Dis. 1996 Jun;11(2):143-52. doi: 10.1007/BF02069501.
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Release of [3H]-noradrenaline from rat hippocampal synaptosomes by nicotine: mediation by different nicotinic receptor subtypes from striatal [3H]-dopamine release.尼古丁诱导大鼠海马突触体释放[3H]-去甲肾上腺素：与纹状体[3H]-多巴胺释放中不同烟碱受体亚型的介导作用。
Br J Pharmacol. 1996 Feb;117(4):595-606. doi: 10.1111/j.1476-5381.1996.tb15232.x.
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N-methyl-D-aspartate receptor antagonist MK-801 induced circling behavior in rats with unilateral striatal ischemic lesions or nigral 6-hydroxydopamine lesions.N-甲基-D-天冬氨酸受体拮抗剂MK-801可诱导单侧纹状体缺血性损伤或黑质6-羟基多巴胺损伤的大鼠出现转圈行为。
Acta Neuropathol. 1993;86(5):480-3. doi: 10.1007/BF00228583.
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Treatment of Parkinson's disease.帕金森病的治疗。
West J Med. 1994 Sep;161(3):303-8.
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The pharmacology of the nicotinic antagonist, chlorisondamine, investigated in rat brain and autonomic ganglion.在大鼠脑和自主神经节中对烟碱拮抗剂氯异吲哚铵的药理学进行了研究。
Br J Pharmacol. 1994 Feb;111(2):397-405. doi: 10.1111/j.1476-5381.1994.tb14748.x.
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The NMDA antagonist procyclidine, but not ifenprodil, enhances the protective efficacy of common antiepileptics against maximal electroshock-induced seizures in mice.N-甲基-D-天冬氨酸（NMDA）拮抗剂丙环定能增强常用抗癫痫药对小鼠最大电休克诱发癫痫的保护效果，但艾芬地尔却不能。
J Neural Transm Gen Sect. 1994;97(1):1-12. doi: 10.1007/BF01277958.
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Effect of dizocilpine (MK-801) on the catalepsy induced by delta 9-tetrahydrocannabinol in mice.地佐环平（MK - 801）对δ9 - 四氢大麻酚诱导的小鼠僵住症的影响。
J Neural Transm Gen Sect. 1994;95(2):137-43. doi: 10.1007/BF01276432.