Goto S, Korematsu K, Inoue N, Yamada K, Oyama T, Nagahiro S, Ushio Y
Department of Neurosurgery, Kumamoto University Medical School, Japan.
Acta Neuropathol. 1993;86(5):480-3. doi: 10.1007/BF00228583.
The present study shows that systemic administration of the selective, non-competitive N-methyl-D-aspartate antagonist MK-801 [(+)-5-methyl-10,11-dihydroxy-5H-dibenzo (a,d)-cyclohepten-5,10-imine] dose-dependently induces ipsiversive rotational behavior in the rats with a unilateral striatal lesion produced by transient middle cerebral artery occlusion or in those with a unilateral nigrostriatal lesion produced by 6-hydroxydopamaine. In relation to a functional model of the basal ganglia-thalamocortical 'motor' circuit, the present data suggest that the striatum may be one of the most important sites where MK-801 acts in the basal ganglia, with its being responsible for the circling behavior of the animal models.
本研究表明，对因短暂大脑中动脉闭塞所致单侧纹状体损伤的大鼠或因6-羟基多巴胺所致单侧黑质纹状体损伤的大鼠，全身给予选择性、非竞争性N-甲基-D-天冬氨酸拮抗剂MK-801 [（+）-5-甲基-10,11-二羟基-5H-二苯并（a，d）-环庚烯-5,10-亚胺]可剂量依赖性地诱导其向患侧旋转行为。就基底神经节-丘脑皮质“运动”回路的功能模型而言，目前的数据表明，纹状体可能是MK-801在基底神经节中发挥作用的最重要位点之一，它可导致动物模型的转圈行为。
