辅助钯催化直接 C(sp^2)-H 磺酰胺化反应合成 1,2-氨基醇衍生物。
Auxiliary-Assisted Palladium-Catalyzed Direct C(sp)-H Sulfonamidation To Afford 1,2-Amino Alcohol Derivatives.
机构信息
School of Pharmaceutical Sciences, Tsinghua University , Haidian District, Beijing 100084, PR China.
出版信息
J Org Chem. 2017 Apr 7;82(7):3864-3872. doi: 10.1021/acs.joc.6b02975. Epub 2017 Mar 13.
PMID:28262020
Abstract
An auxiliary-assisted Pd-catalyzed C(sp)-H sulfonamidation approach using NFSI as both nitrogen source and oxidant to afford 1,2-amino alcohol derivatives is described in this paper. This method is novel and attractive because of its high yields, wide range of substrate scopes, and good tolerance for many functional groups. Oximido and sulfonyl group can be removed with this method.
摘要
本文描述了一种使用 NFSI 作为氮源和氧化剂的辅助 Pd 催化 C(sp)-H 磺酰胺化方法，用于合成 1,2-氨基醇衍生物。该方法具有高产率、广泛的底物范围和对许多官能团的良好耐受性等优点，是一种新颖而有吸引力的方法。此外，该方法还可以去除肟基和磺酰基。
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