Takahashi Michio, Matsui Mie, Nakashima Mitsuhiro, Takahashi Tsutomu, Suzuki Michio
Department of Psychology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama, Japan.
Department of Psychology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, 2630 Sugitani, Toyama, Japan; Institute of Liberal Arts and Science, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa, Japan.
Asian J Psychiatr. 2017 Feb;25:197-202. doi: 10.1016/j.ajp.2016.10.031. Epub 2016 Nov 19.
Previous studies have reported a reduction in the size of the corpus callosum (CC) on the mid-sagittal plane in patients with schizophrenia. However, findings for the size of the callosal area in patients with first-episode schizophrenia (FESz) are inconsistent. A possibility for these conflicting results is that the duration of illness in patients with FESz affects the CC size. The present study investigated the CC size abnormalities in patients with FESz. Forty-six patients with FESz whose duration of illness was less than 1year and 46 age-, sex-, and handedness-matched healthy controls were recruited to examine the CC size using magnetic resonance imaging. We measured the area of the CC using the Witelson's scheme, which divided the whole area into seven subdivisions. Analysis of covariance indicated there was no difference in the whole or regional areas of the CC between patients with FESz and healthy controls. The rostrum of the CC was significantly correlated with the total score for negative symptoms and some of the subtotal scores. Our findings indicate that there was no reduction in the whole or regional area of the CC among patients with FESz. When comparing the callosal morphology and symptoms, negative symptoms increased in severity as the rostrum area of the CC decreased in size. Further studies are needed to investigate whether the size of the anterior CC is associated with the pathology observed in the early stages of FESz.
以往研究报告称，精神分裂症患者矢状中面上的胼胝体（CC）体积减小。然而，首发精神分裂症（FESz）患者胼胝体区域大小的研究结果并不一致。这些相互矛盾的结果可能是因为FESz患者的病程影响了CC的大小。本研究调查了FESz患者的CC大小异常情况。招募了46名病程少于1年的FESz患者以及46名年龄、性别和利手相匹配的健康对照者，使用磁共振成像检查CC大小。我们采用Witelson方案测量CC的面积，该方案将整个区域划分为七个亚区。协方差分析表明，FESz患者与健康对照者在CC的整体或区域面积上没有差异。CC的嘴部与阴性症状总分及部分子总分显著相关。我们的研究结果表明，FESz患者的CC整体或区域面积没有减小。在比较胼胝体形态和症状时，随着CC嘴部面积减小，阴性症状的严重程度增加。需要进一步研究来调查CC前部的大小是否与FESz早期观察到的病理情况相关。
