Del Re Elisabetta C, Konishi Jun, Bouix Sylvain, Blokland Gabriëlla A M, Mesholam-Gately Raquelle I, Goldstein Jill, Kubicki Marek, Wojcik Joanne, Pasternak Ofer, Seidman Larry J, Petryshen Tracey, Hirayasu Yoshio, Niznikiewicz Margaret, Shenton Martha E, McCarley Robert W
Laboratory of Neuroscience, Department of Psychiatry, VA Boston Healthcare System, Brockton Division, Brockton, MA, USA.
Harvard Medical School, Boston, MA, USA.
Brain Imaging Behav. 2016 Dec;10(4):1264-1273. doi: 10.1007/s11682-015-9493-2.
The lateral and third ventricles, as well as the corpus callosum (CC), are known to be affected in schizophrenia. Here we investigate whether abnormalities in the lateral ventricles (LVs), third ventricle, and corpus callosum are related to one another in first episode schizophrenia (FESZ), and whether such abnormalities show progression over time. Nineteen FESZ and 19 age- and handedness-matched controls were included in the study. MR images were acquired on a 3-Tesla MRI at baseline and ~1.2 years later. FreeSurfer v.5.3 was employed for segmentation. Two-way or univariate ANCOVAs were used for statistical analysis, where the covariate was intracranial volume. Group and gender were included as between-subjects factors. Percent volume changes between baseline and follow-up were used to determine volume changes at follow-up. Bilateral LV and third ventricle volumes were significantly increased, while central CC volume was significantly decreased in patients compared to controls at baseline and at follow-up. In FESZ, the bilateral LV volume was also inversely correlated with volume of the central CC. This inverse correlation was not present in controls. In FESZ, an inverse correlation was found between percent volume increase from baseline to follow-up for bilateral LVs and lesser improvement in the Global Assessment of Functioning score. Significant correlations were observed for abnormalities of central CC, LVs and third ventricle volumes in FESZ, suggesting a common neurodevelopmental origin in schizophrenia. Enlargement of ventricles was associated with less improvement in global functioning over time.
已知精神分裂症会影响侧脑室和第三脑室以及胼胝体（CC）。在此，我们研究首次发作精神分裂症（FESZ）患者的侧脑室（LVs）、第三脑室和胼胝体异常是否相互关联，以及这些异常是否随时间进展。本研究纳入了19例FESZ患者以及19例年龄和用手习惯匹配的对照。在基线时和大约1.2年后使用3特斯拉磁共振成像（MRI）获取图像。使用FreeSurfer v.5.3进行分割。采用双向或单变量协方差分析进行统计分析，协变量为颅内体积。将组和性别作为受试者间因素纳入。使用基线和随访之间的体积百分比变化来确定随访时的体积变化。在基线和随访时，与对照组相比，患者的双侧LVs和第三脑室体积显著增加，而中央CC体积显著减小。在FESZ患者中，双侧LVs体积也与中央CC体积呈负相关。对照组中不存在这种负相关。在FESZ患者中，发现从基线到随访期间双侧LVs体积增加百分比与功能总体评定量表评分改善较少之间存在负相关。在FESZ患者中，观察到中央CC、LVs和第三脑室体积异常之间存在显著相关性，提示精神分裂症存在共同的神经发育起源。脑室扩大与随时间推移总体功能改善较少相关。
