左旋肉碱治疗前后肥胖儿童和青少年血清趋化素水平与非酒精性脂肪性肝病及代谢综合征其他特征的关系
Serum Chemerin in Obese Children and Adolescents Before and After L-Carnitine Therapy: Relation to Nonalcoholic Fatty Liver Disease and Other Features of Metabolic Syndrome.
机构信息
Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
出版信息
Arch Med Res. 2016 Oct;47(7):541-549. doi: 10.1016/j.arcmed.2016.11.010.
BACKGROUND AND AIMS
Chemerin plays an important role in metabolic syndrome (MetS) including nonalcoholic fatty liver disease (NAFLD). L-carnitine (LC) may reduce plasma glucose, lipid profile, and improve liver function. The aim of the study was to assess serum chemerin in obese children with suspected NAFLD, the effect of LC on NAFLD grade, chemerin and metabolic profile.
METHODS
Fifty obese children were compared to 50 controls. All were subjected to anthropometric assessment, liver function, fasting lipid profile, glucose/insulin (G/I) ratio, homeostasis model assessment (HOMA) index, serum chemerin and abdominal ultrasonography before and after LC.
RESULTS
Serum chemerin was higher in cases than controls. Eighty percent of cases had NAFLD with increase in chemerin as severity of NAFLD increased. There was a decrease in frequency of NAFLD and its severity after LC therapy.
CONCLUSIONS
Noninvasive monitoring of serum chemerin in obese patients with suspected NAFLD could be used to diagnose NAFLD. LC supplementation is effective in treatment of NAFLD and reducing chemerin.
背景与目的
趋化素在代谢综合征（MetS）中发挥着重要作用，包括非酒精性脂肪性肝病（NAFLD）。左旋肉碱（LC）可能降低血糖、血脂谱，并改善肝功能。本研究旨在评估疑似 NAFLD 的肥胖儿童的血清趋化素水平，LC 对 NAFLD 分级、趋化素和代谢特征的影响。
方法
将 50 例肥胖儿童与 50 例对照进行比较。所有受试者均进行人体测量评估、肝功能、空腹血脂谱、血糖/胰岛素（G/I）比值、稳态模型评估（HOMA）指数、血清趋化素和腹部超声检查，在 LC 治疗前后进行。
结果
病例组血清趋化素高于对照组。80%的病例存在 NAFLD，随着 NAFLD 严重程度的增加，趋化素水平也升高。LC 治疗后，NAFLD 的频率和严重程度均降低。
结论
疑似 NAFLD 的肥胖患者血清趋化素的非侵入性监测可用于诊断 NAFLD。LC 补充治疗对 NAFLD 有效，并降低趋化素水平。
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