成年男性的血清脂质异常与非酒精性脂肪性肝病

Serum Lipid Abnormalities and Nonalcoholic Fatty Liver Disease in Adult Males.

作者信息

Peng Keping, Mo Zengnan, Tian Guixiang

机构信息

Department of Otorhinolaryngology-Head and Neck surgery, the First Hospital of Hunan University of Chinese Medical, Changsha, Hunan, China.

Institute of Urology and Nephrology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.

出版信息

Am J Med Sci. 2017 Mar;353(3):236-241. doi: 10.1016/j.amjms.2017.01.002. Epub 2017 Jan 11.

DOI:10.1016/j.amjms.2017.01.002

PMID:28262209

Abstract

BACKGROUND

Dyslipidemia is a risk factor for nonalcoholic fatty liver disease (NAFLD). The aim of our study was to determine the associations of serum lipid indexes with NAFLD in adult males.

MATERIALS AND METHODS

In this cross-sectional study, 830 patients with NAFLD and 2,357 healthy individuals were assessed. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol and low-density lipoprotein cholesterol (LDL-C) levels were compared between patients with NAFLD and controls. The associations of dyslipidemia indexes with NAFLD occurrence were assessed by univariate analysis, and multivariate analysis was performed to identify independent dyslipidemia factors predictive of NAFLD.

RESULTS

Of the 3,187 study subjects, NAFLD occurred in 830 (26.04%), there were 504 (60.72%) patients with mild disease and 326 (39.28%) patients with moderate-to-severe disease. Although the frequency of normal TC, TG, LDL-C and high-density lipoprotein cholesterol levels in patients with NAFLD was similar to the controls, the frequencies of patients with NAFLD with marginally high and high TC, TG and LDL-C levels were significantly different when compared with controls. Interestingly, the association of the number of abnormal serum lipid indexes and NAFLD was highly significant with 2 abnormalities (odds ratio = 1.977; 95% CI: 1.436-2.722; P < 0.001) and ≥3 abnormalities (odds ratio = 3.505; 95% CI: 2.466-4.982; P < 0.001).

CONCLUSIONS

A significant positive association was found between dyslipidemia characteristics and NAFLD in adult males.

摘要

背景

血脂异常是非酒精性脂肪性肝病（NAFLD）的一个危险因素。我们研究的目的是确定成年男性血清脂质指标与NAFLD之间的关联。

材料与方法

在这项横断面研究中，评估了830例NAFLD患者和2357名健康个体。比较了NAFLD患者与对照组的血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇（LDL-C）水平。通过单因素分析评估血脂异常指标与NAFLD发生的关联，并进行多因素分析以确定预测NAFLD的独立血脂异常因素。

结果

在3187名研究对象中，830例（26.04%）发生了NAFLD，其中轻度疾病患者504例（60.72%），中度至重度疾病患者326例（39.28%）。虽然NAFLD患者中TC、TG、LDL-C和高密度脂蛋白胆固醇水平正常的频率与对照组相似，但与对照组相比，NAFLD患者中TC、TG和LDL-C水平略高和高的频率有显著差异。有趣的是，血清脂质指标异常数量与NAFLD的关联在有2项异常时非常显著（比值比=1.977；95%可信区间：1.436 - 2.722；P < 0.001），≥3项异常时也非常显著（比值比=3.505；95%可信区间：2.466 - 4.982；P < 0.001）。