总胆固醇与高密度脂蛋白胆固醇比值是预测非酒精性脂肪肝的一个重要指标：金昌队列研究。
Total cholesterol to high-density lipoprotein cholesterol ratio is a significant predictor of nonalcoholic fatty liver: Jinchang cohort study.
机构信息
Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Basic Medical College, Lanzhou University, Lanzhou, Gansu, 730000, People's Republic of China.
Institute of Epidemiology and Statistics, School of Public Health, Lanzhou University, Lanzhou, 730000, Gansu, People's Republic of China.
出版信息
Lipids Health Dis. 2019 Feb 11;18(1):47. doi: 10.1186/s12944-019-0984-9.
BACKGROUND
Some studies found out that TC/HDL-C ratio is a predictor of Cardiovascular disease (CVD) and Nonalcoholic fatty liver (NAFLD) is related to CVD. And some researches have already studied that Apolipoprotein B to Apolipoprotein A1 ratio (ApoB/ApoA1) and Triglyceride to High-density lipoprotein cholesterol ratio (TG/HDL-C) were both related with CVD and NAFLD, but few studied the association between TC/HDL-C ratio and NAFLD. So, we suspected the ratio was also related to NAFLD. The research aims to study the predictive value of TC/HDL-C to NAFLD and to help the early detection of NAFLD.
METHODS
Based on the Jinchang Cohort, the study contained 32,121 participants. We assessed the incidence of NAFLD by the quartiles of TC, HDL-C and TC/HDL-C. Then, the does-response relationship between these indicators and the risk of NAFLD was obtained. Finally, the receiver operator characteristic curve (ROC) was applied to decide the predictive value of TC/HDL-C.
RESULTS
Among the study participants, the cumulative incidence of NAFLD was 6.30% and the rate of dyslipidemia was 40.37%. The biochemical indicators of NAFLD had a difference with general population. The incidence of NAFLD raised with the quartiles of TC, TG and LDL-C raising, while decreased with the HDL-C' quartiles raising. After controlling confounding factors, TC and TC/HD-C had a positive relationship with NAFLD, while HDL-C had the opposite. Finally, the ROC analysis showed the area under the curve (AUC) of TC/HDL-C (0.645) was greater than TC (0.554), HDL-C (0.627) and Apolipoprotein B to Apolipoprotein A1 (ApoB/ApoA1) (0.613).
CONCLUSIONS
The TC/HDL-C ratio has significant predictive value to NAFLD.
背景
一些研究发现 TC/HDL-C 比值是心血管疾病 (CVD) 的预测因子，非酒精性脂肪肝 (NAFLD) 与 CVD 有关。一些研究已经表明载脂蛋白 B 与载脂蛋白 A1 的比值 (ApoB/ApoA1) 和甘油三酯与高密度脂蛋白胆固醇的比值 (TG/HDL-C) 均与 CVD 和 NAFLD 相关，但很少有研究探讨 TC/HDL-C 比值与 NAFLD 的关系。因此，我们怀疑该比值也与 NAFLD 相关。本研究旨在探讨 TC/HDL-C 比值对 NAFLD 的预测价值，以期帮助早期发现 NAFLD。
方法
基于金昌队列，该研究纳入了 32121 名参与者。我们根据 TC、HDL-C 和 TC/HDL-C 的四分位数评估 NAFLD 的发生率。然后，我们获得了这些指标与 NAFLD 风险之间的剂量-反应关系。最后，我们应用受试者工作特征曲线 (ROC) 来确定 TC/HDL-C 的预测价值。
结果
在研究参与者中，NAFLD 的累积发病率为 6.30%，血脂异常发生率为 40.37%。NAFLD 的生化指标与一般人群不同。随着 TC、TG 和 LDL-C 四分位数的升高，NAFLD 的发病率升高，而随着 HDL-C 四分位数的升高，发病率降低。在控制混杂因素后，TC 和 TC/HD-C 与 NAFLD 呈正相关，而 HDL-C 则相反。最后，ROC 分析显示 TC/HDL-C（0.645）的曲线下面积（AUC）大于 TC（0.554）、HDL-C（0.627）和载脂蛋白 B 与载脂蛋白 A1 的比值（ApoB/ApoA1）（0.613）。
结论
TC/HDL-C 比值对 NAFLD 有显著的预测价值。
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