移植中的性别差异。
Sex differences in transplantation.
机构信息
Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego/La Jolla, CA.
Kidney Transplant/Department of Pharmacy Services, UC San Diego Health System, University of California, San Diego/La Jolla, CA.
出版信息
Transplant Rev (Orlando). 2017 Jul;31(3):145-150. doi: 10.1016/j.trre.2017.02.003. Epub 2017 Feb 20.
Abstract
Sex plays a role in the incidence and progression of a wide variety of diseases and conditions related to transplantation. Additionally, a growing body of clinical and experimental evidence suggests that sex can impact the pharmacokinetics and pharmacodynamics of several commonly used immunosuppressive and anti-infective drugs in transplant recipients. A better understanding of these sex differences will facilitate advances in individualizing treatment for patients and improve outcomes of solid organ transplantation. Here, we provide a review of sex-related differences in transplantation and highlight opportunities for future research directions.
摘要
性别在与移植相关的各种疾病和病症的发生和进展中起着一定的作用。此外，越来越多的临床和实验证据表明，性别可以影响几种常用于移植受者的免疫抑制剂和抗感染药物的药代动力学和药效动力学。更好地了解这些性别差异将有助于为患者制定个体化治疗方案，并改善实体器官移植的结果。在这里，我们对移植中的性别相关差异进行了综述，并强调了未来研究方向的机会。
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J Pediatr Surg. 2015 Jun;50(6):996-9. doi: 10.1016/j.jpedsurg.2015.03.021. Epub 2015 Mar 14.
2
Influence of sex and race on mycophenolic acid pharmacokinetics in stable African American and Caucasian renal transplant recipients.性别和种族对稳定期非裔美国人和白人肾移植受者霉酚酸药代动力学的影响。
Clin Pharmacokinet. 2015 Apr;54(4):423-34. doi: 10.1007/s40262-014-0213-7.
3
Individualised prediction of alternate-day aspirin treatment effects on the combined risk of cancer, cardiovascular disease and gastrointestinal bleeding in healthy women.健康女性隔日服用阿司匹林对癌症、心血管疾病和胃肠道出血综合风险影响的个体化预测
Heart. 2015 Mar;101(5):369-76. doi: 10.1136/heartjnl-2014-306342. Epub 2014 Dec 4.
4
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Nature. 2014 May 15;509(7500):282-3. doi: 10.1038/509282a.
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