Thompson Austin, Omil-Lima Danly, Perez Jaime Abraham, Jesse Erin, Khera Mohit, Chavin Kenneth, Thirumavalavan Nannan
Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Fox Chase Cancer Center at Temple University, Philadelphia, PA, USA.
Int J Impot Res. 2024 Jun 5. doi: 10.1038/s41443-024-00921-7.
Hypogonadism is understudied in men requiring solid organ transplants, particularly among lung transplant recipients. Improvement in serum testosterone levels has been reported in kidney and liver transplantation. Using the TriNetX Research Network, we performed a retrospective cohort study to evaluate the incidence of peri-transplant hypogonadism and the natural course of serum testosterone following successful lung transplantation. Men aged ≥ 18 with a lung transplant and total testosterone drawn within one year pre- and post-transplant were included. Men with receipt of testosterone therapy were excluded. A low testosterone (<300 ng/dL) and normal testosterone (≥300 ng/dL) cohort was created before employing descriptive and analytic statistics to investigate the incidence of peri-transplant hypogonadism and the change in serum testosterone levels following lung transplantation. In our entire cohort, lung transplantation was not associated with a significant increase in post-transplant serum testosterone (329.86 ± 162.56 ng/dL pre-transplant and 355.13 ± 216.11 ng/dL post-transplant, p = 0.483). The number of men with low testosterone decreased by 9.8% following lung transplantation but was not significant, p = 0.404. In this pilot study, no significant change in the number of hypogonadal men nor serum testosterone levels was observed among men undergoing lung transplantation.
性腺功能减退在需要实体器官移植的男性中研究较少，尤其是在肺移植受者中。肾移植和肝移植后血清睾酮水平有所改善。我们利用TriNetX研究网络进行了一项回顾性队列研究，以评估移植前后性腺功能减退的发生率以及成功肺移植后血清睾酮的自然变化过程。纳入年龄≥18岁、在肺移植前后一年内检测过总睾酮的男性。接受睾酮治疗的男性被排除。在采用描述性和分析性统计方法调查移植前后性腺功能减退的发生率以及肺移植后血清睾酮水平变化之前，创建了低睾酮（<300 ng/dL）和正常睾酮（≥300 ng/dL）队列。在我们的整个队列中，肺移植与移植后血清睾酮的显著增加无关（移植前为329.86±162.56 ng/dL，移植后为355.13±216.11 ng/dL，p = 0.483）。肺移植后睾酮水平低的男性数量减少了9.8%，但不显著，p = 0.404。在这项初步研究中，接受肺移植的男性中性腺功能减退男性的数量和血清睾酮水平均未观察到显著变化。
