采用自下而上策略制备单链 DNA 包裹的纳米颗粒。
Bottom-Up Strategy To Prepare Nanoparticles with a Single DNA Strand.
机构信息
Department of Chemistry, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign , Urbana, Illinois 61801, United States.
出版信息
J Am Chem Soc. 2017 Mar 15;139(10):3623-3626. doi: 10.1021/jacs.7b00065. Epub 2017 Mar 6.
Abstract
We describe the preparation of cross-linked, polymeric organic nanoparticles (ONPs) with a single, covalently linked DNA strand. The structure and functionalities of the ONPs are controlled by the synthesis of their parent linear block copolymers that provide monovalency, fluorescence and narrow size distribution. The ONP can also guide the deposition of chloroaurate ions allowing gold nanoparticles (AuNPs) to be prepared using the ONPs as templates. The DNA strand on AuNPs is shown to preserve its functions.
摘要
我们描述了具有单个共价连接 DNA 链的交联、聚合有机纳米颗粒 (ONP) 的制备方法。通过合成其母体线性嵌段共聚物来控制 ONP 的结构和功能，该共聚物提供单价、荧光和窄的尺寸分布。ONP 还可以引导氯金酸离子的沉积，从而可以使用 ONP 作为模板制备金纳米颗粒 (AuNP)。AuNP 上的 DNA 链被证明保留了其功能。
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