Key Laboratory of Environmentally Friendly Chemistry of the Ministry of Education, College of Chemistry, Xiangtan University , Xiangtan, Hunan 411105, P. R. China.
CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences (CAS), University of Chinese Academy of Sciences , Beijing 100190, P. R. China.
Org Lett. 2017 Mar 17;19(6):1458-1461. doi: 10.1021/acs.orglett.7b00419. Epub 2017 Mar 6.
The first asymmetric hydrogenation of phenanthridines catalyzed by chiral cationic ruthenium diamine complexes has been developed with up to 92% ee and full conversions. The choice of the counteranion of the catalyst was found to be critical for achieving high enantioselectivity. In addition, the obtained 5,6-dihydrophenanthridine could be used as a chiral hydride donor for organocatalytic asymmetric transfer hydrogenation.
手性阳离子钌二胺配合物首次实现了菲啶类化合物的不对称氢化反应，产物ee 值最高可达 92%，转化率为 100%。研究发现，催化剂抗衡阴离子的选择对于获得高对映选择性至关重要。此外，所得的 5,6-二氢菲啶可作为手性氢供体用于有机催化的不对称转移氢化反应。
