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红细胞储存过程中脂质和蛋白质的积累：白细胞去除术和实验性过滤的作用

The accumulation of lipids and proteins during red blood cell storage: the roles of leucoreduction and experimental filtration.

作者信息

Silliman Christopher C, Burke Timothy, Kelher Marguerite R

机构信息

Bonfils Blood Center, Denver, CO, United States of America.

Department of Pediatrics, School of Medicine, University of Colorado Denver, Aurora, CO, United States of America.

出版信息

Blood Transfus. 2017 Mar;15(2):131-136. doi: 10.2450/2017.0314-16.

DOI:10.2450/2017.0314-16
PMID:28263170
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5336334/
Abstract

Pre-storage leucoreduction has been universally adopted in most developed countries in Asia, Europe and the Americas. It decreases febrile transfusion reactions, alloimmunisation to HLA antigens, cytomegalovirus exposure, the accumulation of a number of pro-inflammatory mediators in the supernatant, including the accumulation of platelet-and leucocyte-derived proteins and metabolites during routine storage. This review will highlight the lipids and proteins, biological response modifiers (BRMs) that accumulate, their clinical effects in transfused hosts, and methods of mitigation.

摘要

在亚洲、欧洲和美洲的大多数发达国家，储存前白细胞滤除已被普遍采用。它可减少发热性输血反应、对HLA抗原的同种免疫、巨细胞病毒暴露，以及上清液中多种促炎介质的积累，包括常规储存期间血小板和白细胞衍生蛋白质及代谢产物的积累。本综述将重点介绍储存期间积累的脂质、蛋白质、生物反应调节剂（BRM）、它们在受血者中的临床效应以及缓解方法。

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本文引用的文献

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Vox Sang. 2017 Jan;112(1):25-32. doi: 10.1111/vox.12453. Epub 2016 Oct 19.
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Blood-Borne Lipopolysaccharide Is Rapidly Eliminated by Liver Sinusoidal Endothelial Cells via High-Density Lipoprotein.肝脏窦状内皮细胞通过高密度脂蛋白快速清除血源性脂多糖。
J Immunol. 2016 Sep 15;197(6):2390-9. doi: 10.4049/jimmunol.1600702. Epub 2016 Aug 17.
3
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Transfusion. 2016 Oct;56(10):2560-2570. doi: 10.1111/trf.13748. Epub 2016 Aug 12.
4
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Transfusion. 2016 Mar;56(3):773-4. doi: 10.1111/trf.13457.
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Transfusion of 35-Day Stored RBCs in the Presence of Endotoxemia Does Not Result in Lung Injury in Humans.在内毒素血症情况下输注储存35天的红细胞不会导致人类肺部损伤。
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