Sut Caroline, Tariket Sofiane, Chou Ming Li, Garraud Olivier, Laradi Sandrine, Hamzeh-Cognasse Hind, Seghatchian Jerard, Burnouf Thierry, Cognasse Fabrice
GIMAP-EA3064, Lyon University, Saint Etienne, France.
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Blood Transfus. 2017 Mar;15(2):145-152. doi: 10.2450/2017.0343-16.
Red blood cell (RBC) transfusion is a life-saving treatment for several pathologies. RBCs for transfusion are stored refrigerated in a preservative solution, which extends their shelf-life for up to 42 days. During storage, the RBCs endure abundant physicochemical changes, named RBC storage lesions, which affect the overall quality standard, the functional integrity and in vivo survival of the transfused RBCs. Some of the changes occurring in the early stages of the storage period (for approximately two weeks) are reversible but become irreversible later on as the storage is extended. In this review, we aim to decipher the duration of RBC storage and inflammatory marker generation. This phenomenon is included as one of the causes of transfusion-related immunomodulation (TRIM), an emerging concept developed to potentially elucidate numerous clinical observations that suggest that RBC transfusion is associated with increased inflammatory events or effects with clinical consequence.
红细胞（RBC）输血是多种病症的一种挽救生命的治疗方法。用于输血的红细胞保存在含有保存液的冷藏环境中，这可将其保质期延长至42天。在储存期间，红细胞会经历大量的物理化学变化，即所谓的红细胞储存损伤，这会影响输血红细胞的整体质量标准、功能完整性和体内存活率。储存期早期（约两周）发生的一些变化是可逆的，但随着储存时间延长，后期会变得不可逆。在本综述中，我们旨在解读红细胞储存的持续时间以及炎症标志物的产生。这种现象被视为输血相关免疫调节（TRIM）的原因之一，TRIM是一个新兴概念，旨在潜在地解释众多临床观察结果，这些观察结果表明红细胞输血与炎症事件增加或具有临床后果的效应相关。
