Ogawa Elisa F, Leveille Suzanne G, Wright Julie A, Shi Ling, Camhi Sarah M, You Tongjian
1Department of Exercise and Health Sciences, University of Massachusetts Boston, Boston, MA; 2Department of Nursing, College of Nursing and Health Sciences, University of Massachusetts Boston, Boston, MA; 3Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA; and 4Department of Medicine, Harvard Medical School, Boston, MA.
Med Sci Sports Exerc. 2017 Jul;49(7):1375-1382. doi: 10.1249/MSS.0000000000001253.
The purpose of this study was to examine the associations between different physical activity (PA) domains, PA recommendations, and leukocyte telomere length (LTL) using data from a nationally representative sample of U.S. adults in the National Health and Nutrition Examination Survey, 1999-2002.
A total of 6933 U.S. adults (3402 men, 3531 women; age range: 20-84 yr) who completed demographic, general health and PA questionnaires and provided a blood sample were included in the analyses. Multivariable-adjusted linear regression models were used to determine associations between PA (domain-specific PA [household/yard work PA, transportation PA, moderate leisure time PA (LTPA), and vigorous LTPA], total moderate PA and PA recommendation groups), and log-transformed LTL adjusting for age, gender, education, cigarette smoking, alcohol consumption, and body mass index.
On average, an increase of 1 h·wk of vigorous LTPA was associated with a 0.31% (P < 0.001) longer LTL, and an increase of 1 h·wk of household/yard work PA was associated with a 0.21% (P = 0.03) shorter LTL while adjusted for sociodemographic and health behavior covariates. Neither transportation PA nor moderate LTPA was significantly associated with LTL. In addition, compared with not meeting the PA recommendation (<150 min·wk), exceeding the recommended PA levels (≥300 min·wk) was positively associated with longer LTL (P = 0.04), whereas there was no difference in telomere length between those not meeting versus those meeting the PA recommendation (150-299 min·wk).
Greater engagement in vigorous LTPA and exceeding the PA recommendation may have a protective effect against telomere shortening. Future studies should examine the association between PA and LTL by exploring potential mediators such as sedentary behavior, genetics, nutrition, and chronic diseases.
本研究旨在利用1999 - 2002年美国国家健康与营养检查调查中具有全国代表性的美国成年人样本数据，研究不同身体活动（PA）领域、PA建议与白细胞端粒长度（LTL）之间的关联。
共有6933名美国成年人（3402名男性，3531名女性；年龄范围：20 - 84岁）纳入分析，这些人完成了人口统计学、一般健康状况和PA问卷调查，并提供了血样。多变量调整线性回归模型用于确定PA（特定领域PA[家务/庭院工作PA、交通PA、中度休闲时间PA（LTPA）和剧烈LTPA]、总中度PA和PA建议组）与经年龄、性别、教育程度、吸烟、饮酒和体重指数调整的对数转换LTL之间的关联。
平均而言，在调整社会人口统计学和健康行为协变量后，剧烈LTPA每周增加1小时与LTL延长0.31%（P < 0.001）相关，家务/庭院工作PA每周增加1小时与LTL缩短0.21%（P = 0.03）相关。交通PA和中度LTPA均与LTL无显著关联。此外，与未达到PA建议（<150分钟/周）相比，超过推荐的PA水平（≥300分钟/周）与更长的LTL呈正相关（P = 0.04），而未达到PA建议者与达到PA建议者（150 - 299分钟/周）之间的端粒长度没有差异。
更多地参与剧烈LTPA和超过PA建议可能对端粒缩短具有保护作用。未来的研究应通过探索久坐行为、遗传学、营养和慢性病等潜在中介因素来研究PA与LTL之间的关联。
