美国成年人中基于运动的行为与白细胞端粒长度
Movement-Based Behaviors and Leukocyte Telomere Length among US Adults.
作者信息
Loprinzi Paul D, Loenneke Jeremy P, Blackburn Elizabeth H
机构信息
1Center for Health Behavior Research, Department of Health, Exercise Science, and Recreation Management, University of Mississippi, University, MS; 2Kevser Ermin Applied Physiology Laboratory, Department of Health, Exercise Science, and Recreation Management, University of Mississippi, University, MS; and 3Blackburn Laboratory, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA.
出版信息
Med Sci Sports Exerc. 2015 Nov;47(11):2347-52. doi: 10.1249/MSS.0000000000000695.
INTRODUCTION
Short leukocyte telomere length (LTL) has become a hallmark characteristic of aging. Some, but not all, evidence suggests that physical activity (PA) may play an important role in attenuating age-related diseases and may provide a protective effect for telomeres. The purpose of this study was to examine the association between PA and LTL in a national sample of US adults from the National Health and Nutrition Examination Survey.
METHODS
National Health and Nutrition Examination Survey data from 1999 to 2002 (n = 6503; 20-84 yr) were used. Four self-report questions related to movement-based behaviors (MBB) were assessed. The four MBB included whether individuals participated in moderate-intensity PA, vigorous-intensity PA, walking/cycling for transportation, and muscle-strengthening activities. An MBB index variable was created by summing the number of MBB an individual engaged in (range, 0-4).
RESULTS
A clear dose-response relation was observed between MBB and LTL; across the LTL tertiles, respectively, the mean numbers of MBB were 1.18, 1.44, and 1.54 (Ptrend < 0.001). After adjustments (including age) and compared with those engaging in 0 MBB, those engaging in 1, 2, 3, and 4 MBB, respectively, had a 3% (P = 0.84), 24% (P = 0.02), 29% (P = 0.04), and 52% (P = 0.004) reduced odds of being in the lowest (vs highest) tertile of LTL; MBB was not associated with being in the middle (vs highest) tertile of LTL.
CONCLUSIONS
Greater engagement in MBB was associated with reduced odds of being in the lowest LTL tertile.
引言
白细胞端粒长度（LTL）缩短已成为衰老的一个标志性特征。一些（但并非全部）证据表明，体育活动（PA）可能在减轻与年龄相关的疾病方面发挥重要作用，并且可能对端粒提供保护作用。本研究的目的是在来自美国国家健康与营养检查调查的全国成年人群样本中，检验PA与LTL之间的关联。
方法
使用了1999年至2002年的美国国家健康与营养检查调查数据（n = 6503；年龄20 - 84岁）。评估了四个与基于运动的行为（MBB）相关的自我报告问题。这四个MBB包括个体是否参与中等强度PA、高强度PA、步行/骑自行车出行以及肌肉强化活动。通过将个体参与的MBB数量相加（范围为0 - 4）创建了一个MBB指数变量。
结果
在MBB与LTL之间观察到明显的剂量反应关系；在LTL三分位数中，MBB的平均数量分别为1.18、1.44和1.54（P趋势<0.001）。经过调整（包括年龄）后，与参与0项MBB的人相比，参与1、2、3和4项MBB的人处于LTL最低（与最高）三分位数的几率分别降低了3%（P = 0.84）、24%（P = 0.02）、29%（P = 0.04）和52%（P = 0.004）；MBB与处于LTL中间（与最高）三分位数无关。
结论
更多地参与MBB与处于LTL最低三分位数的几率降低有关。
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