Hayes M C, Scully R E
Department of Pathology, Harvard Medical School, Boston, Massachusetts.
Int J Gynecol Pathol. 1987;6(4):313-21. doi: 10.1097/00004347-198712000-00003.
The clinical and pathological features of 25 stromal luteomas were reviewed. The patients ranged in age from 28-74 (average 58.4) years. The most common initial manifestation (60%) was abnormal vaginal bleeding; three patients (12%) were virilized. The tumors, only one of which was bilateral, ranged from 0.25-2.9 (average 1.3) cm in greatest diameter. They were all well circumscribed. Microscopic examination revealed unencapsulated nodules composed of rounded polyhedral cells that were arranged either diffusely or in nests and cords. Twenty percent showed degeneration within aggregates of cell resulting in the formation of pseudoacinar structures. The cytoplasm of the neoplastic cells was generally eosinophilic and granular, and lipochrome granules were present in over half the tumors. In 92% of the cases hyperthecosis was present in the adjacent ovarian stroma. Follow-up of 6 months to 17 years was available for 19 patients. Sixteen of them were alive and free of disease; the remaining three died of other causes. The benign course in all the cases in which follow-up data were available was expected in view of the small size of the tumors and their benign microscopic appearance.
对25例间质黄体瘤的临床和病理特征进行了回顾性研究。患者年龄在28岁至74岁之间（平均58.4岁）。最常见的初始表现（60%）为阴道异常出血；3例患者（12%）出现男性化表现。肿瘤最大直径为0.25至2.9厘米（平均1.3厘米），仅1例为双侧性。所有肿瘤边界均清晰。显微镜检查显示，肿瘤由未被包膜包裹的结节组成，结节由圆形多面体细胞构成，这些细胞呈弥漫性排列或呈巢状、条索状排列。20%的肿瘤在细胞聚集体内出现退变，形成假腺泡结构。肿瘤细胞的细胞质通常呈嗜酸性且颗粒状，超过半数的肿瘤中存在脂色素颗粒。92%的病例中，相邻卵巢间质存在卵泡膜细胞增生。19例患者有6个月至17年的随访资料。其中16例存活且无疾病；其余3例死于其他原因。鉴于肿瘤体积小且显微镜下表现为良性，所有有随访资料的病例预后均良好。
