Paraskevas M, Scully R E
Department of Pathology, University of Manitoba Health Sciences Centre, Winnipeg, Canada.
Int J Gynecol Pathol. 1989;8(4):299-310.
The clinical and pathological features of 12 Reinke crystal-positive and nine probable (crystal-negative) hilus cell tumors of the ovary were reviewed. The patients' ages ranged from 32 to 82 years. The initial manifestation was androgenic in 62% of the cases. The levels of testosterone were high (200-2,400 ng/dl) even though the tumors had a mean diameter of only 2.1 cm. All the tumors were centered in the hilus of the ovary, extending for varying distances into the ovarian stroma. They were composed of polyhedral to rounded cells with generally abundant eosinophilic cytoplasm and often showed a perivascular aggregation of nuclei with avascular pooling of cytoplasm or hyalinization of stroma. Fibrinoid changes in the vessels of the tumors were frequently noted. None of the 10 patients for whom follow-up data of 1-17 years were available died of tumor; virilizing symptoms regressed but did not completely disappear in five of the 10 patients after the removal of the tumor.
回顾了12例雷氏晶体阳性和9例可能（晶体阴性）的卵巢门细胞瘤的临床和病理特征。患者年龄在32岁至82岁之间。62%的病例初始表现为雄激素过多。尽管肿瘤平均直径仅2.1厘米，但睾酮水平很高（200 - 2400纳克/分升）。所有肿瘤均位于卵巢门，向卵巢间质延伸不同距离。它们由多面体至圆形细胞组成，细胞质通常丰富嗜酸性，常显示核周血管聚集，细胞质无血管池或间质透明变性。肿瘤血管中纤维蛋白样改变常见。在有1至17年随访数据的10例患者中，无1例死于肿瘤；10例患者中有5例在肿瘤切除后男性化症状消退但未完全消失。
