Katsu-Jiménez Yurika, Alves Renato M P, Giménez-Cassina Alfredo
Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Scheeles väg 2, 171 77 Stockholm, Sweden.
Karolinska Institutet, Department of Medical Biochemistry and Biophysics, Scheeles väg 2, 171 77 Stockholm, Sweden; Centro de Biología Molecular "Severo Ochoa", Universidad Autónoma de Madrid, Department of Molecular Biology, C/ Nicolás Cabrera 1, 28049 Madrid, Spain.
Exp Cell Res. 2017 Nov 1;360(1):41-46. doi: 10.1016/j.yexcr.2017.03.002. Epub 2017 Mar 3.
Neuronal excitability is a highly demanding process that requires high amounts of energy and needs to be exquisitely regulated. For this reason, brain cells display active energy metabolism to support their activity. Independently of their roles as energy substrates, compelling evidence shows that the nature of the fuels that neurons use contribute to fine-tune neuronal excitability. Crosstalk of neurons with glial populations also plays a prominent role in shaping metabolic flow in the brain. In this review, we provide an overview on how different carbon substrates and metabolic pathways impact neurotransmission, and the potential implications for neurological disorders in which neuronal excitability is deregulated, such as epilepsy.
神经元兴奋性是一个要求极高的过程，需要大量能量，且需要精确调节。因此，脑细胞表现出活跃的能量代谢以支持其活动。尽管它们作为能量底物发挥作用，但有力证据表明，神经元所使用燃料的性质有助于微调神经元兴奋性。神经元与神经胶质细胞群之间的相互作用在塑造大脑代谢流方面也起着重要作用。在本综述中，我们概述了不同碳底物和代谢途径如何影响神经传递，以及对神经元兴奋性失调的神经系统疾病（如癫痫）的潜在影响。
