Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Mol Aspects Med. 2017 Dec;58:1-11. doi: 10.1016/j.mam.2017.03.001. Epub 2017 Mar 3.
It is with great pleasure that I write this foreword and introduction to this Special Issue dedicated to the protective actions of the pro-resolving mediators and edited by my colleague Dr. Jesmond Dalli. Many of my collaborators and colleagues that helped to uncover the actions and clinical potential of the resolvins and other specialized proresolving mediators (SPM), namely, the superfamily of pro-resolving mediators that includes the resolvin (E-series, D-series and DPA-derived), protectin and maresin families, as well as the arachidonic acid-derived lipoxins, join me in this special issue. They have given contributions that present exciting new results on the remarkable actions and potency of these unique molecules, the SPM moving forward the importance of their mediators and pathways in human biology. Each contribution to this issue is presented by world authorities in their respective fields covering discoveries that demonstrate the importance and impact of resolution mediators in biology, medicine and surgery. While some of the authors were students and/or fellows with me and others, they are today the founding "resolutionists" of a new era of appreciation of autacoid biosynthesis and metabolomics in human health and disease with their rigorous attention to experimental detail and discovery. The chapters of this issue are filled with exciting new discoveries demonstrating the dynamics and potential of resolution mediators.
我非常高兴为这本专门探讨促炎消退介质保护作用的特刊写这篇前言和介绍，这本特刊由我的同事 Jesmond Dalli 博士编辑。我的许多合作者和同事帮助揭示了消退素和其他特殊促炎消退介质（SPM）的作用和临床潜力，包括促炎消退介质的超级家族，其中包括消退素（E 系列、D 系列和 DPA 衍生的）、保护素和maresin 家族，以及花生四烯酸衍生的脂氧素，他们都加入了这个特刊。他们的贡献展示了这些独特分子的令人兴奋的新结果和显著作用，这些 SPM 进一步强调了它们的介质和途径在人类生物学中的重要性。本期特刊的每一篇文章都由各自领域的世界权威作者撰写，涵盖了一些研究成果，这些研究成果表明了在生物学、医学和外科学中，消退介质的重要性和影响。其中一些作者曾经是我的学生和/或研究员，而另一些则是今天在人类健康和疾病中自主生物合成和代谢组学领域的开创性人物，他们对实验细节和发现有着严谨的关注。本期特刊的章节充满了令人兴奋的新发现，展示了消退介质的动态和潜力。
