Toor E W, Evans D F, Cussler E L
Proc Natl Acad Sci U S A. 1978 Dec;75(12):6230-4. doi: 10.1073/pnas.75.12.6230.
The growth of cholesterol monohydrate from solutions of bile salt, lecithin, and small electrolytes has been studied by microscopy and with the Coulter Counter. The crystal forms found by microscopy are the same as those seen in human gallstones and in squirrel monkey cholesterol microliths. The cholesterol growth rates determined with the Coulter Counter vary slowly with cholesterol concentration at low degree of supersaturation but become exponential at higher cholesterol concentrations. Growth is accelerated by the presence of calcium and magnesium but inhibited by potassium. These results can be combined with previous measurements of cholesterol dissolution rates to give a more accurate picture of the dynamics of gallstone formation.
通过显微镜和库尔特计数器研究了胆固醇一水合物在胆盐、卵磷脂和小电解质溶液中的生长情况。显微镜下发现的晶体形态与人类胆结石和松鼠猴胆固醇微结石中的相同。用库尔特计数器测定的胆固醇生长速率在低过饱和度时随胆固醇浓度缓慢变化，但在较高胆固醇浓度时呈指数变化。钙和镁的存在会加速生长，而钾则会抑制生长。这些结果可以与先前对胆固醇溶解速率的测量结果相结合，以更准确地描绘胆结石形成的动态过程。
