• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

帕金森病大鼠高频丘脑底核刺激后纹状体谷氨酸和γ-氨基丁酸的变化

Striatal Glutamate and GABA after High Frequency Subthalamic Stimulation in Parkinsonian Rat.

作者信息

Lee Kyung Jin, Shim Insop, Sung Jae Hoon, Hong Jae Taek, Kim Il Sup, Cho Chul Bum

机构信息

Department of Neurosurgery, Yeoido Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Acupuncture & Meridian Science Research Center, College of Oriental Medicine, Kyung Hee University, Seoul, Korea.

出版信息

J Korean Neurosurg Soc. 2017 Mar;60(2):138-145. doi: 10.3340/jkns.2016.0202.020. Epub 2017 Mar 1.

DOI:10.3340/jkns.2016.0202.020
PMID:28264233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5365293/
Abstract

OBJECTIVE

High frequency stimulation (HFS) of the subthalamic nucleus (STN) is recognized as an effective treatment of advanced Parkinson's disease. However, the neurochemical basis of its effects remains unknown. The aim of this study is to investigate the effects of STN HFS in intact and 6-hydroxydopamine (6-OHDA)-lesioned hemiparkinsonian rat model on changes of principal neurotransmitters, glutamate, and gamma-aminobutyric acid (GABA) in the striatum.

METHODS

The authors examined extracellular glutamate and GABA change in the striatum on sham group, 6-OHDA group, and 6-OHDA plus deep brain stimulation (DBS) group using microdialysis methods.

RESULTS

High-pressure liquid chromatography was used to quantify glutamate and GABA. The results show that HFS-STN induces a significant increase of extracellular glutamate and GABA in the striatum of 6-OHDA plus DBS group compared with sham and 6-OHDA group.

CONCLUSION

Therefore, the clinical results of STN-HFS are not restricted to the direct STN targets but involve widespread adaptive changes within the basal ganglia.

摘要

目的

丘脑底核高频刺激（HFS）被认为是治疗晚期帕金森病的一种有效方法。然而，其作用的神经化学基础仍不清楚。本研究旨在探讨丘脑底核高频刺激对完整和6-羟基多巴胺（6-OHDA）损伤的偏侧帕金森病大鼠模型纹状体中主要神经递质、谷氨酸和γ-氨基丁酸（GABA）变化的影响。

方法

作者采用微透析法检测假手术组、6-OHDA组和6-OHDA加脑深部刺激（DBS）组纹状体细胞外谷氨酸和GABA的变化。

结果

采用高压液相色谱法定量谷氨酸和GABA。结果显示，与假手术组和6-OHDA组相比，丘脑底核高频刺激可使6-OHDA加DBS组纹状体细胞外谷氨酸和GABA显著增加。

结论

因此，丘脑底核高频刺激的临床效果不仅限于丘脑底核的直接靶点，还涉及基底神经节内广泛的适应性变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a25/5365293/159f78f7b38c/jkns-60-2-138f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a25/5365293/f51531658157/jkns-60-2-138f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a25/5365293/635a1f01374e/jkns-60-2-138f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a25/5365293/b0d7111d36d1/jkns-60-2-138f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a25/5365293/1b6e99539349/jkns-60-2-138f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a25/5365293/159f78f7b38c/jkns-60-2-138f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a25/5365293/f51531658157/jkns-60-2-138f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a25/5365293/635a1f01374e/jkns-60-2-138f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a25/5365293/b0d7111d36d1/jkns-60-2-138f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a25/5365293/1b6e99539349/jkns-60-2-138f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a25/5365293/159f78f7b38c/jkns-60-2-138f5.jpg

相似文献

1
Striatal Glutamate and GABA after High Frequency Subthalamic Stimulation in Parkinsonian Rat.帕金森病大鼠高频丘脑底核刺激后纹状体谷氨酸和γ-氨基丁酸的变化
J Korean Neurosurg Soc. 2017 Mar;60(2):138-145. doi: 10.3340/jkns.2016.0202.020. Epub 2017 Mar 1.
2
Neurochemical mechanisms induced by high frequency stimulation of the subthalamic nucleus: increase of extracellular striatal glutamate and GABA in normal and hemiparkinsonian rats.高频刺激丘脑底核诱导的神经化学机制：正常和偏侧帕金森病大鼠纹状体细胞外谷氨酸和γ-氨基丁酸的增加
J Neuropathol Exp Neurol. 2003 Dec;62(12):1228-40. doi: 10.1093/jnen/62.12.1228.
3
Pallidal origin of GABA release within the substantia nigra pars reticulata during high-frequency stimulation of the subthalamic nucleus.丘脑底核高频刺激期间黑质网状部内GABA释放的苍白球起源
J Neurosci. 2005 May 18;25(20):5079-86. doi: 10.1523/JNEUROSCI.0360-05.2005.
4
Metabolic, synaptic and behavioral impact of 5-week chronic deep brain stimulation in hemiparkinsonian rats.5周慢性深部脑刺激对偏侧帕金森病大鼠的代谢、突触和行为影响
J Neurochem. 2016 Mar;136(5):1004-16. doi: 10.1111/jnc.13438. Epub 2015 Dec 21.
5
Effect of Subthalamic Stimulation and Electrode Implantation in the Striatal Microenvironment in a Parkinson's Disease Rat Model.帕金森病大鼠模型底丘脑刺激和电极植入对纹状体微环境的影响。
Int J Mol Sci. 2022 Oct 11;23(20):12116. doi: 10.3390/ijms232012116.
6
High frequency stimulation of subthalamic nucleus results in behavioral recovery by increasing striatal dopamine release in 6-hydroxydopamine lesioned rat.高频刺激丘脑底核通过增加6-羟基多巴胺损伤大鼠纹状体多巴胺释放来实现行为恢复。
Behav Brain Res. 2014 Apr 15;263:108-14. doi: 10.1016/j.bbr.2014.01.014. Epub 2014 Jan 23.
7
The subthalamic activity and striatal monoamine are modulated by subthalamic stimulation.丘脑底核刺激可调节丘脑底核活动和纹状体单胺。
Neuroscience. 2014 Feb 14;259:43-52. doi: 10.1016/j.neuroscience.2013.11.034. Epub 2013 Nov 27.
8
Progressive brain metabolic changes under deep brain stimulation of subthalamic nucleus in parkinsonian rats.帕金森病大鼠丘脑底核深部脑刺激下的渐进性脑代谢变化
J Neurochem. 2015 Mar;132(6):703-12. doi: 10.1111/jnc.13015. Epub 2015 Feb 12.
9
Subthalamic deep brain stimulation alters neuronal firing in canonical pain nuclei in a 6-hydroxydopamine lesioned rat model of Parkinson's disease.丘脑底核深部脑刺激改变帕金森病 6-羟多巴胺损伤大鼠模型中经典痛核神经元的放电。
Exp Neurol. 2016 Sep;283(Pt A):298-307. doi: 10.1016/j.expneurol.2016.06.031. Epub 2016 Jul 1.
10
Long term high frequency stimulation of STN increases dopamine in the corpus striatum of hemiparkinsonian rhesus monkey.长期高频刺激丘脑底核可增加偏侧帕金森恒河猴纹状体内的多巴胺。
Brain Res. 2009 Aug 25;1286:230-8. doi: 10.1016/j.brainres.2009.06.069. Epub 2009 Jun 27.

引用本文的文献

1
Mechanisms of nucleus accumbens deep brain stimulation in treating mental disorders.伏隔核深部脑刺激治疗精神障碍的机制。
Fundam Res. 2024 Jul 6;5(1):48-54. doi: 10.1016/j.fmre.2024.06.009. eCollection 2025 Jan.
2
Effect of Subthalamic Stimulation and Electrode Implantation in the Striatal Microenvironment in a Parkinson's Disease Rat Model.帕金森病大鼠模型底丘脑刺激和电极植入对纹状体微环境的影响。
Int J Mol Sci. 2022 Oct 11;23(20):12116. doi: 10.3390/ijms232012116.
3
Feasibility of Measuring GABA Levels in the Upper Brainstem in Healthy Volunteers Using Edited MRS.

本文引用的文献

1
Movement disorders and neuromodulation.运动障碍与神经调节
Neurol Res Int. 2012;2012:309431. doi: 10.1155/2012/309431. Epub 2012 Sep 19.
2
Deep-Brain Stimulation for Basal Ganglia Disorders.用于基底神经节疾病的深部脑刺激
Basal Ganglia. 2011 Jul 1;1(2):65-77. doi: 10.1016/j.baga.2011.05.001.
3
Milestones in research on the pathophysiology of Parkinson's disease.帕金森病病理生理学研究的里程碑。
使用编辑后的磁共振波谱法测量健康志愿者上脑干中γ-氨基丁酸水平的可行性
Front Psychiatry. 2020 Aug 14;11:813. doi: 10.3389/fpsyt.2020.00813. eCollection 2020.
4
Change of Extracellular Glutamate Level in Striatum during Deep Brain Stimulation of the Entopeduncular Nucleus in Rats.大鼠内苍白球深部脑刺激期间纹状体细胞外谷氨酸水平的变化
J Korean Neurosurg Soc. 2019 Mar;62(2):166-174. doi: 10.3340/jkns.2018.0122. Epub 2019 Feb 27.
Mov Disord. 2011 May;26(6):1032-41. doi: 10.1002/mds.23695.
4
Mechanisms and functional implications of adult neurogenesis.成体神经发生的机制及其功能意义。
Cell. 2008 Feb 22;132(4):645-60. doi: 10.1016/j.cell.2008.01.033.
5
High-frequency stimulation of the subthalamic nucleus prolongs the increase in striatal dopamine induced by acute l-3,4-dihydroxyphenylalanine in dopaminergic denervated rats.高频刺激丘脑底核可延长多巴胺能去神经大鼠中由急性左旋3,4-二羟基苯丙氨酸诱导的纹状体多巴胺增加的时间。
Eur J Neurosci. 2007 Sep;26(6):1670-80. doi: 10.1111/j.1460-9568.2007.05747.x. Epub 2007 Sep 6.
6
Deep brain stimulation in a rat model modulates TH, CaMKIIa and Homer1 gene expression.大鼠模型中的深部脑刺激调节酪氨酸羟化酶、钙/钙调蛋白依赖性蛋白激酶IIα和荷马1基因的表达。
Eur J Neurosci. 2007 Jan;25(1):239-50. doi: 10.1111/j.1460-9568.2006.05264.x.
7
A new approach to understand the pathophysiology of Parkinson's disease.一种理解帕金森病病理生理学的新方法。
J Neurol. 2005 Oct;252 Suppl 4:IV1-IV4. doi: 10.1007/s00415-005-4002-y.
8
Long-term effects of bilateral subthalamic nucleus stimulation in advanced Parkinson disease: a four year follow-up study.双侧丘脑底核刺激对晚期帕金森病的长期影响：一项四年随访研究。
Parkinsonism Relat Disord. 2005 May;11(3):157-65. doi: 10.1016/j.parkreldis.2004.10.011.
9
Complex locking rather than complete cessation of neuronal activity in the globus pallidus of a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primate in response to pallidal microstimulation.在1-甲基-4-苯基-1,2,3,6-四氢吡啶处理的灵长类动物中，苍白球对苍白球微刺激的反应是复杂的锁定而非神经元活动完全停止。
J Neurosci. 2004 Aug 18;24(33):7410-9. doi: 10.1523/JNEUROSCI.1691-04.2004.
10
Uncovering the mechanism(s) of action of deep brain stimulation: activation, inhibition, or both.揭示深部脑刺激的作用机制：激活、抑制，还是两者兼有。
Clin Neurophysiol. 2004 Jun;115(6):1239-48. doi: 10.1016/j.clinph.2003.12.024.