Chmel Roman, Nováčková Marta, Pastor Zlatko, Matěcha Jan, Čekal Miloš, Froněk Jiří
Cas Lek Cesk. 2017 Winter;156(1):28-35.
Uterus transplantation is a novel experimental method of female infertility treatment. It is an appropriate treatment modality for women with absolute uterine factor infertility - congenital uterine malformations, absent uterus, hysterectomized women and non-functional uterus.Successful animal studies confirming the safety and efficacy were performed before introduction of uterus transplantation into human medicine. The first clinical trial was performed in 2012-2013 in Gothenburg, Sweden. The first child from the transplanted womb was delivered in 2014. Concerning the promising results of Swedish trial it is essential to perform trials in some other world centers.In 2015 Czech Ministry of Health permitted uterus transplantation trial in cooperation of two Prague hospitals - namely Institute for Clinical and Experimental Medicine and University Hospital Motol. The aim of the Czech trial is to reassert feasibility, efficacy and safety of uterus transplantation in two groups of women - 10 recipients from living and 10 from deceased brain donor. We believe that detailed and precise long-term theoretic and practical preparation and perfectly arranged trial are the main conditions of the successful uterine transplantation survey. The first Czech uterus transplantation was performed in April 30, 2016.Up to December 2016 four transplantations out of planned 20 (2 in living donor and 2 in deceased brain donor arm) were carried out by our team.
子宫移植是一种治疗女性不孕症的新型实验方法。对于患有绝对子宫因素不孕症的女性——先天性子宫畸形、无子宫、子宫切除术后女性以及无功能子宫的女性而言，这是一种合适的治疗方式。在将子宫移植引入人类医学之前，已经进行了成功的动物研究，证实了其安全性和有效性。2012年至2013年在瑞典哥德堡进行了首例临床试验。2014年，首例通过移植子宫孕育的婴儿诞生。鉴于瑞典试验取得了令人鼓舞的结果，在世界其他一些中心开展试验至关重要。2015年，捷克卫生部批准了在布拉格的两家医院——临床与实验医学研究所和莫托尔大学医院合作进行子宫移植试验。捷克试验的目的是在两组女性中再次确认子宫移植的可行性、有效性和安全性——10名活体供体受体和10名脑死亡供体受体。我们认为，详细而精确的长期理论和实践准备以及精心安排的试验是成功进行子宫移植研究的主要条件。首例捷克子宫移植于2016年4月30日进行。截至2016年12月，我们的团队在计划的20例移植手术中完成了4例（2例活体供体移植和2例脑死亡供体移植）。
