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[原发性肝癌中肿瘤碎片和/或血凝块导致肝外胆管梗阻。诊断和治疗问题。附9例个人病例及文献复习]

[Obstruction of the extrahepatic bile ducts by tumor debris and/or clots in primary cancer of the liver. Diagnostic and therapeutic problems. Apropos of 9 personal cases and review of the literature].

作者信息

Guntz M, Boyer J, Ronceray J, Lorimier G, Cronier P, Delaby J

机构信息

Clinique Chirurgicale A, C.H.U. Angers.

出版信息

J Chir (Paris). 1987 Aug-Sep;124(8-9):432-49.

PMID:2826513
Abstract

The onset of jaundice in patients with primary liver cancer is sometimes caused by intra ductal biliary system tumor casts, free floating debris or hemobilia. The diagnosis of this complication is now possible by E.R.C.P. or P.T.C. We report 9 cases of unrecognized primary liver tumor revealed by intra biliary system migration of tumor casts or free floating debris. In three patients the diagnosis was operative, but for the last six cases the E.R.C.P. data in addition with U.S., C.A.T. Scan and/or hepatic angiography were helpful in determining the nature of the hepatic and biliary changes, the operability (size, location, extent). A curative surgery was not indicated in our 8 operated patients: liver resection and biliary decompression. With the palliative procedures, bilio enteric by pass (2 cases) T tube (1 case) trans hepatic uni or bilateral tubes. The survey was not longer than 11 months. Three patients died in post operative course. Only 56 patients among 117 observations of the literature have been operated: 10 liver resections including the main hepatic junction in two cases were performed with one hospital death, two patients were alive over 2 years with recurrence and three patients were disease free with a follow up less than one year. The operative mortality with palliative procedures was 34.4%; the one-two years survival was 23%; the two longest survivors lived 41 and 61 months.

摘要

原发性肝癌患者黄疸的出现有时是由肝内胆管系统肿瘤栓子、游离漂浮物或胆道出血引起的。现在通过内镜逆行胰胆管造影(ERCP)或经皮肝穿刺胆管造影(PTC)可以诊断这种并发症。我们报告了9例因肿瘤栓子或游离漂浮物在肝内胆管系统迁移而被发现的未被识别的原发性肝肿瘤病例。其中3例患者通过手术确诊,但对于后6例患者,ERCP数据结合超声、计算机断层扫描(CAT)和/或肝血管造影有助于确定肝脏和胆道改变的性质、可手术性(大小、位置、范围)。在我们8例接受手术的患者中未进行根治性手术:肝切除和胆道减压。采用姑息性手术,包括胆肠吻合术(2例)、T管引流(1例)、经肝单管或双管引流。观察时间不超过11个月。3例患者在术后死亡。在文献报道的117例观察病例中,只有56例患者接受了手术:10例进行了肝切除术,其中2例包括主要肝门部,有1例医院死亡,2例患者存活超过2年且复发,3例患者无疾病生存,随访时间不到1年。姑息性手术的手术死亡率为34.4%;1至2年生存率为23%;最长的2例存活者分别存活了41个月和61个月。

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