[具体物质名称]在雄性小鼠中的抗伤害感受作用。 （你提供的原文中“of”后面缺少具体物质，这里补充了“[具体物质名称]”以便完整理解句子意思）
Antinociceptive action of in male mice.
作者信息
Leite Laura Inocencio, Leite Gerlânia de Oliveira, Fernandes Silva Bruno Anderson, Gonçalves Sousa Severino Denício, Coutinho Thales Silva, Sampaio Renata Souza, Menezes Irwin, Martins Costa José Galberto, Campos Adriana Rolim
机构信息
Department of Biology at the Federal University of Cariri, Brejo Santo - CE, Brazil.
Department of Pharmacology, University of Santa Maria, Santa Maria- RS, Brazil.
出版信息
Avicenna J Phytomed. 2017 Jan-Feb;7(1):93-98.
OBJECTIVE
Baker (Asteraceae) has high economic value from Chapada to Araripe and its bark essential oil is a potential source of alpha-bisabolol. The present study aimed to elucidate the antinociceptive and antipruritic properties of the essential oil of Baker (EOVA) in mice.
MATERIALS AND METHODS
The antinociceptive activity was assessed using the capsaicin, glutamate, hot plate and cold allodynia tests. The antipuritic effects were also verified based on histamine-induced scratching behavior.
RESULTS
EOVA reduced the paw licking induced by capsaicin, but not that induced by glutamate. The essential oil increased the latency time in the hot plate, attenuated the cold allodynia induced by acetone and inhibited histamine-induced scratching behavior.
CONCLUSION
The experimental data demonstrated that EOVA showed central and peripheral antinociceptive activity and antipruritic effect.
目的
贝克氏菊（菊科）从查帕达到阿拉里皮具有很高的经济价值，其树皮精油是α-红没药醇的潜在来源。本研究旨在阐明贝克氏菊精油（EOVA）对小鼠的抗伤害感受和止痒特性。
材料与方法
使用辣椒素、谷氨酸、热板和冷痛觉过敏试验评估抗伤害感受活性。还基于组胺诱导的抓挠行为验证了止痒效果。
结果
EOVA减少了辣椒素诱导的舔爪行为，但未减少谷氨酸诱导的舔爪行为。该精油增加了热板试验中的潜伏期，减轻了丙酮诱导的冷痛觉过敏，并抑制了组胺诱导的抓挠行为。
结论
实验数据表明，EOVA具有中枢和外周抗伤害感受活性以及止痒作用。
Zotero 插件