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花椒精油的镇痛活性

Antinociceptive Activity of Zanthoxylum piperitum DC. Essential Oil.

作者信息

Donald Graciela Rocha, Fernandes Patrícia Dias, Boylan Fabio

机构信息

Federal University of Rio de Janeiro, Institute of Biomedical Sciences, Avenida Carlos Chagas Filho 373, CCS, Laboratory J10, 21941-902 Rio de Janeiro, RJ, Brazil.

School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.

出版信息

Evid Based Complement Alternat Med. 2016;2016:3840398. doi: 10.1155/2016/3840398. Epub 2016 Jul 31.

DOI:10.1155/2016/3840398
PMID:27547225
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4983354/
Abstract

Zanthoxylum piperitum DC. (ZP) is a traditional medicinal plant used mainly in countries from Asia such as Japan. This study aimed to investigate the antinociceptive effect of ZP essential oil (ZPEO). The major component present in the essential oil was beta-phellandrene (29.39%). Its antinociceptive activity was tested through animal models (formalin-, capsaicin-, and glutamate-induced paw licking and hot plate). The anti-inflammatory effect was evaluated through the carrageenan-induced leukocyte migration into the subcutaneous air pouch (SAP), with measurement of cytokines. The results showed antinociceptive effect for ZPEO for the first phase of the formalin-induced licking, glutamate, and hot plate tests. However, ZPEO had no effect on reducing paw licking induced by capsaicin. Finally, ZPEO had no effect against inflammation induced by carrageenan.

摘要

花椒（Zanthoxylum piperitum DC.，简称ZP）是一种传统药用植物，主要在亚洲国家如日本使用。本研究旨在探究花椒精油（ZPEO）的镇痛作用。该精油中的主要成分是β-水芹烯（29.39%）。通过动物模型（福尔马林、辣椒素和谷氨酸诱导的舔足以及热板法）测试了其镇痛活性。通过角叉菜胶诱导白细胞迁移至皮下气囊（SAP）并检测细胞因子来评估其抗炎作用。结果显示，ZPEO对福尔马林诱导舔足的第一阶段、谷氨酸和热板试验具有镇痛作用。然而，ZPEO对辣椒素诱导的舔足没有降低作用。最后，ZPEO对角叉菜胶诱导的炎症没有作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb2/4983354/d001666a24dc/ECAM2016-3840398.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb2/4983354/d2da7dbec835/ECAM2016-3840398.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb2/4983354/2954c93e6544/ECAM2016-3840398.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb2/4983354/ee618afc2a86/ECAM2016-3840398.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb2/4983354/333e671e600e/ECAM2016-3840398.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb2/4983354/c82fc78efe93/ECAM2016-3840398.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb2/4983354/30f53ba7f39e/ECAM2016-3840398.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb2/4983354/3b84cafc0b41/ECAM2016-3840398.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb2/4983354/d001666a24dc/ECAM2016-3840398.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb2/4983354/d2da7dbec835/ECAM2016-3840398.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb2/4983354/2954c93e6544/ECAM2016-3840398.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb2/4983354/ee618afc2a86/ECAM2016-3840398.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb2/4983354/333e671e600e/ECAM2016-3840398.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb2/4983354/c82fc78efe93/ECAM2016-3840398.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb2/4983354/30f53ba7f39e/ECAM2016-3840398.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb2/4983354/3b84cafc0b41/ECAM2016-3840398.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdb2/4983354/d001666a24dc/ECAM2016-3840398.008.jpg

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