银屑病面积和严重程度指数（PASI）改善90%的银屑病患者在健康相关生活质量方面的改善程度高于PASI改善75%-89%的患者：司库奇尤单抗两项3期研究的结果。
Psoriasis patients with psoriasis Area and Severity Index (PASI) 90 response achieve greater health-related quality-of-life improvements than those with PASI 75-89 response: results from two phase 3 studies of secukinumab.
作者信息
Elewski Boni E, Puig Lluís, Mordin Margaret, Gilloteau Isabelle, Sherif Bintu, Fox Todd, Gnanasakthy Ari, Papavassilis Charis, Strober Bruce E
机构信息
a University of Alabama at Birmingham , Birmingham , AL , USA.
b Department of Dermatology , Hospital de la Sanat Creu i Sant Pau , Barcelona , Spain.
出版信息
J Dermatolog Treat. 2017 Sep;28(6):492-499. doi: 10.1080/09546634.2017.1294727. Epub 2017 Mar 7.
BACKGROUND
The emergence of new biological therapies showing high and sustained level of Psoriasis Area and Severity Index (PASI) 90 response has provided the possibility of both greater skin clearance and increased quality of life (QOL).
OBJECTIVE
To evaluate the association of greater response in skin clearance with improvements in skin-related QOL up to 52 weeks.
METHODS
Subjects achieving various levels of skin clearance (PASI 90-100 or PASI 75-89) and Dermatology Life Quality Index (DLQI) (0/1) response were compared using ERASURE and FIXTURE trial data. Similar analyses with IGA ratings of Clear or Almost Clear were performed.
RESULTS
Significantly more PASI 90-100 responders at week 12 had DLQI 0/1 response than PASI 75-89 (69.4% vs. 47.1%; p < .001) and sustained DLQI 0/1 response at week 52 (74.0% vs. 56.7%; p < .001). IGA results were similar.
CONCLUSIONS
These results show that PASI 90-100 is a relevant therapeutic goal in moderate to severe psoriasis compared to PASI 75-89 when considering patients' QOL.
背景
新的生物疗法的出现显示出银屑病面积和严重程度指数（PASI）达到90%缓解的高且持续水平，这为实现更大程度的皮肤清除和提高生活质量（QOL）提供了可能。
目的
评估在长达52周的时间里，皮肤清除率更高的反应与皮肤相关生活质量改善之间的关联。
方法
使用ERASURE和FIXTURE试验数据，比较达到不同皮肤清除水平（PASI 90 - 100或PASI 75 - 89）以及皮肤病生活质量指数（DLQI）（0/1）反应的受试者。对IGA评分为清除或几乎清除的情况进行了类似分析。
结果
在第12周时，PASI 90 - 100反应者中DLQI为0/1反应的比例显著高于PASI 75 - 89反应者（69.4%对47.1%；p < 0.001），并且在第52周时持续保持DLQI 0/1反应的比例也更高（74.0%对56.7%；p < 0.001）。IGA结果相似。
结论
这些结果表明，在考虑患者生活质量时，与PASI 75 - 89相比，PASI 90 - 100是中度至重度银屑病的一个相关治疗目标。
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