Song Xiaofei, Song Yucheng, Zhang Xuedong, Xue Huanzhou
1 Department of Gastrointestinal Surgery, The People's Hospital of Zhengzhou University (Henan Provincial People's Hospital) , Zhengzhou, People's Republic of China .
2 Department of Hepatobiliary Surgery, The People's Hospital of Zhengzhou University (Henan Provincial People's Hospital) , Zhengzhou, People's Republic of China .
Surg Infect (Larchmt). 2017 Jul;18(5):577-581. doi: 10.1089/sur.2016.174. Epub 2017 Mar 7.
The aim of the study was to investigate the concentration and diagnostic significance of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in acute abdominal conditions.
Plasma specimens were obtained from 68 patients with abdominal sepsis, 60 patients with systemic inflammatory response syndrome (SIRS), and 60 healthy individuals. The sepsis group was divided into the survival and death groups according to the 28-d outcome. Plasma sTREM-1, procalcitonin (PCT), C-reactive protein (CRP), and white blood cell (WBC) count were measured. A receiver operating characteristic curve (ROC) was used to compare the diagnostic values of sTREM-1, PCT, CRP, and WBC count. In addition, the correlation between plasma sTREM-1 and the Acute Physiology and Chronic Health Evaluation (APACHE) II score in the sepsis group was assessed by Spearman correlation analysis.
The plasma concentration of sTREM-1 in the sepsis group was significantly higher than that in the SIRS and healthy groups (both p < 0.001). Also, the plasma concentration of sTREM-1 in the death group was markedly higher than that in the survival group. The ROC for the diagnosis of sepsis vs. SIRS showed that the area under the curve of sTREM-1 (0.82) was greater than that of PCT (0.77), CRP (0.72), and WBC count (0.70). Additionally, in the sepsis group, the plasma sTREM-1 concentration correlated positively with the APACHE II score (r = 0.41; p < 0.05).
The plasma concentration of sTREM-1 may be a significantly sensitive and useful indicator for the rapid diagnosis of abdominal sepsis.
本研究旨在探讨急性腹部疾病中髓系细胞触发受体-1（sTREM-1）的浓度及其诊断意义。
收集68例腹部脓毒症患者、60例全身炎症反应综合征（SIRS）患者及60例健康个体的血浆标本。脓毒症组根据28天预后分为存活组和死亡组。检测血浆sTREM-1、降钙素原（PCT）、C反应蛋白（CRP）及白细胞（WBC）计数。采用受试者工作特征曲线（ROC）比较sTREM-1、PCT、CRP及WBC计数的诊断价值。此外，通过Spearman相关分析评估脓毒症组血浆sTREM-1与急性生理与慢性健康状况评分系统（APACHE）Ⅱ评分的相关性。
脓毒症组血浆sTREM-1浓度显著高于SIRS组和健康组（均p < 0.001）。而且，死亡组血浆sTREM-1浓度明显高于存活组。脓毒症与SIRS诊断的ROC曲线显示，sTREM-1曲线下面积（0.82）大于PCT（0.77）、CRP（0.7）及WBC计数（0.70）。此外，在脓毒症组，血浆sTREM-1浓度与APACHEⅡ评分呈正相关（r = 0.41；p < 0.05）。
血浆sTREM-1浓度可能是快速诊断腹部脓毒症的一个显著敏感且有用的指标。
