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转录因子Emx2控制感觉毛细胞的静纤毛束方向。

Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells.

作者信息

Jiang Tao, Kindt Katie, Wu Doris K

机构信息

Program in Neuroscience and Cognitive Science, University of Maryland, College Park, United States.

Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, United States.

出版信息

Elife. 2017 Mar 7;6:e23661. doi: 10.7554/eLife.23661.

DOI:10.7554/eLife.23661
PMID:28266911
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5388538/
Abstract

The asymmetric location of stereociliary bundle (hair bundle) on the apical surface of mechanosensory hair cells (HCs) dictates the direction in which a given HC can respond to cues such as sound, head movements, and water pressure. Notably, vestibular sensory organs of the inner ear, the maculae, exhibit a line of polarity reversal (LPR) across which, hair bundles are polarized in a mirror-image pattern. Similarly, HCs in neuromasts of the zebrafish lateral line system are generated as pairs, and two sibling HCs develop opposite hair bundle orientations. Within these sensory organs, expression of the transcription factor Emx2 is restricted to only one side of the LPR in the maculae or one of the two sibling HCs in neuromasts. Emx2 mediates hair bundle polarity reversal in these restricted subsets of HCs and generates the mirror-image pattern of the sensory organs. Downstream effectors of Emx2 control bundle polarity cell-autonomously via heterotrimeric G proteins.

摘要

机械感觉毛细胞（HCs）顶端表面上的静纤毛束（毛束）的不对称定位决定了给定HC对声音、头部运动和水压等线索作出反应的方向。值得注意的是，内耳的前庭感觉器官——黄斑，呈现出一条极性反转线（LPR），跨越该线，毛束以镜像模式极化。同样，斑马鱼侧线系统神经丘中的HCs成对产生，两个同胞HCs发育出相反的毛束方向。在这些感觉器官中，转录因子Emx2的表达仅限于黄斑中LPR的一侧或神经丘中两个同胞HCs之一。Emx2在这些受限的HCs亚群中介导毛束极性反转，并产生感觉器官的镜像模式。Emx2的下游效应器通过异源三聚体G蛋白自主控制毛束极性细胞。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/f244632a6100/elife-23661-resp-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/a62bbc7e9141/elife-23661-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/a50f30cf482f/elife-23661-fig1-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/dcdb26b07130/elife-23661-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/a73553482e46/elife-23661-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/1ed28b0d13bd/elife-23661-fig2-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/dde6b4b37ce3/elife-23661-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/ead17ff75dec/elife-23661-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/0dc4cfd7c86e/elife-23661-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/6b81d07f8f75/elife-23661-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/aa4afc878f79/elife-23661-fig6-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/01a9644827cd/elife-23661-fig6-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/a7ceca3b8332/elife-23661-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/32ee8f93efe9/elife-23661-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/25340e88ac5e/elife-23661-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/eaaca45e6785/elife-23661-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/48c26098e1d2/elife-23661-fig10-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/f244632a6100/elife-23661-resp-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/a62bbc7e9141/elife-23661-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/a50f30cf482f/elife-23661-fig1-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/dcdb26b07130/elife-23661-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/a73553482e46/elife-23661-fig2-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/1ed28b0d13bd/elife-23661-fig2-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/dde6b4b37ce3/elife-23661-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/ead17ff75dec/elife-23661-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/0dc4cfd7c86e/elife-23661-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/6b81d07f8f75/elife-23661-fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/aa4afc878f79/elife-23661-fig6-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/01a9644827cd/elife-23661-fig6-figsupp2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/a7ceca3b8332/elife-23661-fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/32ee8f93efe9/elife-23661-fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/25340e88ac5e/elife-23661-fig9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/eaaca45e6785/elife-23661-fig10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/48c26098e1d2/elife-23661-fig10-figsupp1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c643/5388538/f244632a6100/elife-23661-resp-fig1.jpg

相似文献

[1]
Transcription factor Emx2 controls stereociliary bundle orientation of sensory hair cells.

Elife. 2017-3-7

[2]
Directional selectivity of afferent neurons in zebrafish neuromasts is regulated by Emx2 in presynaptic hair cells.

Elife. 2018-4-19

[3]
Emx2 lineage tracing reveals antecedent patterns of planar polarity in the mouse inner ear.

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[4]
Emx2 regulates hair cell rearrangement but not positional identity within neuromasts.

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[5]
The dark kinase STK32A regulates hair cell planar polarity opposite of EMX2 in the developing mouse inner ear.

Elife. 2023-5-5

[6]
Epithelial Planar Bipolarity Emerges from Notch-Mediated Asymmetric Inhibition of Emx2.

Curr Biol. 2020-3-23

[7]
Live imaging of hair bundle polarity acquisition demonstrates a critical timeline for transcription factor Emx2.

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[8]
Emx2 and early hair cell development in the mouse inner ear.

Dev Biol. 2010-2-10

[9]
EMX2-GPR156-Gαi reverses hair cell orientation in mechanosensory epithelia.

Nat Commun. 2021-5-17

[10]
Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2.

Nat Commun. 2022-10-24

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[7]
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Centriole positioning in epithelial cells and its intimate relationship with planar cell polarity.

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