Xie T, Stathopoulou M G, de Andrés F, Siest G, Murray H, Martin M, Cobaleda J, Delgado A, Lamont J, Peñas-LIedó E, LLerena A, Visvikis-Siest S
UMR INSERM U1122, Interactions Gène-Environnement en Physiopathologie Cardio-Vasculair, Université de Lorraine, Nancy, France.
CICAB Clinical Research Centre, Extremadura University Hospital, Badajoz, Spain.
Transl Psychiatry. 2017 Mar 7;7(3):e1055. doi: 10.1038/tp.2017.36.
Depression is a common, severe, disabling mental disease that affects millions of people of all ages worldwide. Various studies have shown that neurotrophic/growth factors have a key role in depression and, more specifically, vascular endothelial growth factor (VEGF) is implicated in the pathogenesis of depression. The purpose of this study was to investigate the potential links between four VEGF-related single-nucleotide polymorphisms (SNPs), previously identified through a genome-wide association study (GWAS) and depression. The direct effects and epistatic interactions of the four VEGF-related SNPs (rs10738760, rs6921438, rs6993770 and rs4416670) on depression were investigated through a case-control study including 437 individuals diagnosed with depression and 477 healthy volunteers as controls. Gender, age and body mass index influence was additionally analyzed. The SNP rs4416670 was associated with increased risk for depression (OR: 1.60, P: 0.010). This result demonstrates the existence of relationships between VEGF genetic determinants and depression. This novel association reveals new molecular mechanisms suggesting the potential role of VEGF in depression development that could help to promote a personalized prediction for this severe common disease.
抑郁症是一种常见、严重且致残的精神疾病，影响着全球数百万各年龄段的人。各种研究表明，神经营养/生长因子在抑郁症中起关键作用，更具体地说，血管内皮生长因子（VEGF）与抑郁症的发病机制有关。本研究的目的是调查先前通过全基因组关联研究（GWAS）确定的四个VEGF相关单核苷酸多态性（SNP）与抑郁症之间的潜在联系。通过一项病例对照研究，对437名被诊断为抑郁症的个体和477名健康志愿者作为对照，研究了四个VEGF相关SNP（rs10738760、rs6921438、rs6993770和rs4416670）对抑郁症的直接影响和上位性相互作用。此外还分析了性别、年龄和体重指数的影响。SNP rs4416670与抑郁症风险增加相关（比值比：1.60，P值：0.010）。这一结果证明了VEGF基因决定因素与抑郁症之间存在关联。这种新的关联揭示了新的分子机制，表明VEGF在抑郁症发展中的潜在作用，这可能有助于促进对这种严重常见疾病的个性化预测。
