Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
World J Biol Psychiatry. 2012 Sep;13(6):468-73. doi: 10.3109/15622975.2011.624549. Epub 2011 Nov 18.
Immunological differences have previously been associated with depression and suicidal behaviour. Several cytokines have been identified as potentially important in understanding the pathophysiology of mood disorders and suicidality. Here we aimed to identify new inflammatory biomarkers for suicide prediction.
Plasma concentrations of interleukin (IL) 1-a , IL1-b, IL-2, IL-4, IL-6, IL-8, IL-10, interferon-gamma (IFNG), tumor necrosis factor-a (TNF-a), monocyte chemotactic protein-1 (MCP-1), epidermal growth factor (EGF), and vascular endothelial growth factor (VEGF) were measured in 58 suicide attempters with a high throughput automated biochip immunoassay system. Patients were evaluated using the Montgomery-Åsberg Depression Rating Scale (MADRS) and the Suicide Intent Scale (SIS). All patients were followed up for cause of death.
We found significantly lower levels of VEGF in the seven patients who upon a mean follow-up of 13 years were found to have completed suicide. VEGF also showed a trend for negative correlation with the planning subscale of SIS. A trend could be shown for lower IL-2 and for higher IFNG levels in suicide victims.
Our study provides further support for a role of inflammation in the pathophysiology of suicidality. VEGF may be related with suicide risk.
免疫差异先前与抑郁和自杀行为有关。有几种细胞因子被认为对理解心境障碍和自杀的病理生理学具有重要意义。在此，我们旨在为自杀预测确定新的炎症生物标志物。
采用高通量自动化生物芯片免疫分析系统测量了 58 名有高自杀风险的自杀未遂者的白细胞介素（IL）1-a、IL1-b、IL-2、IL-4、IL-6、IL-8、IL-10、干扰素-γ（IFNG）、肿瘤坏死因子-a（TNF-a）、单核细胞趋化蛋白-1（MCP-1）、表皮生长因子（EGF）和血管内皮生长因子（VEGF）的血浆浓度。使用蒙哥马利-Åsberg 抑郁评定量表（MADRS）和自杀意念量表（SIS）对患者进行评估。所有患者都进行了死因随访。
我们发现，在 7 名患者中，VEGF 水平明显较低，这些患者在平均 13 年的随访后被发现已经自杀。VEGF 与 SIS 的计划分量表也呈负相关趋势。自杀受害者的 IL-2 水平较低，IFNG 水平较高。
我们的研究进一步支持炎症在自杀病理生理学中的作用。VEGF 可能与自杀风险有关。
